Neoantigens: promising targets for cancer therapy
2023年1月6日 · Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines, adoptive cell …
A shared neoantigen vaccine combined with immune checkpoint …
2024年3月27日 · Here we evaluated safety and tolerability of a therapeutic vaccine encoding 20 shared neoantigens derived from selected common oncogenic driver mutations as primary …
Neoantigen DNA vaccines are safe, feasible, and induce neoantigen …
2024年11月14日 · Our study demonstrates neoantigen DNA vaccines are safe, feasible, and capable of inducing neoantigen-specific immune responses. NCT02348320. Neoantigen …
Personalized Neoantigen Vaccines for Aggressive Cancers
2024年4月10日 · Researchers at the AACR Annual Meeting 2024 presented the latest findings regarding two personalized neoantigen cancer vaccines.
Personalized RNA neoantigen vaccines stimulate T cells in
2023年5月10日 · Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA …
Personal neoantigen cancer vaccines: a road not fully paved
Personal neoantigen-based cancer vaccines are designed to target antigens arising from tumor-specific mutations within individual cancers and present a tremendous opportunity to capitalize …
Designing neoantigen cancer vaccines, trials, and outcomes
Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed in cancer cells. These highly immunogenic antigens may trigger the immune system to combat …
Neoantigen vaccine: an emerging tumor immunotherapy
2019年8月23日 · Tumor vaccines targeting neoantigens mainly include nucleic acid, dendritic cell (DC)-based, tumor cell, and synthetic long peptide (SLP) vaccines. The combination with …
Individualised neoantigen cancer vaccine therapy - The Lancet
2024年2月17日 · Recent advancements in the understanding of immunogenic cancer epitopes and the improvement of vaccine technology rekindled interest in the concept of a so-called …
The landscape of neoantigens and its clinical ... - ScienceDirect
2024年1月1日 · Neoantigens are more immunogenic than tumor-associated antigens (TAAs) because they lack central tolerance. Successful clinical trials of neoantigen-based vaccines …
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