2023年3月10日 · Ferroptosis, a novel form of cell death defined as iron-mediated lipid peroxidation, has been shown to play a role in the pathogenesis of ARDS. Additionally, pyroptosis and necroptosis are also...

2024年4月10日 · Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV ...

Necroptosis plays an important role in the progression of ALI/ARDS. However, since ALI/ARDS is a clinical syndrome caused by a variety of mechanisms, we emphasize that while focusing on necroptosis, it may be more beneficial to treat ALI/ARDS by collaborating with other mechanisms.

2024年8月28日 · Necroptosis is a type of inflammatory cell death governed by receptor-interacting serine/threonine protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein (MLKL), resulting in the release of intracellular contents and inflammatory factors capable of initiating an inflammatory response in adjacent tissues.

2.3.2. Acute respiratory distress syndrome. Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure caused by noncardiogenic pulmonary edema, characterized by rapidly progressive dyspnea, tachypnea, and hypoxemia.

2024年4月14日 · Necroptosis plays an important role in the systemic inflammatory response, and monitoring necroptosis-related molecules is essential for assessing the severity of ALI/ARDS, guiding clinical treatment, and determining patient prognosis.

Uncontrolled lytic cell death can lead to tissue damage and severe diseases, including acute respiratory distress syndrome (ARDS), neurodegenerative diseases, and inflammatory disorders . Necroptosis creates a rich inflammatory environment by releasing DAMPs and recruiting immune cells and chemotactic or cytokine factors to prevent viral ...

2023年3月10日 · The crosstalk among ferroptosis, pyroptosis, and necroptosis is getting increasing attention. Therefore, this review will mainly summarize the molecular mechanisms and central pathophysiological role of ferroptosis in ARDS. We will also discuss our understanding of pyroptosis and necroptosis as they pertain to the pathogenesis of ARDS.

4 天之前 · Acute respiratory distress syndrome (ARDS) is a critical, life-threatening acute lung injury characterized by non-cardiogenic pulmonary edema and profound hypoxemia, frequently linked to severe infections, trauma, and systemic inflammatory responses [1, 2].Since its initial description in 1967 [], the definition and diagnostic criteria of ARDS have undergone multiple refinements [4, 5].

Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV infection 6-8 and can potentially be targeted by receptor interacting protein kinase 3 (RIPK3) inhibitors.