The series premiered on September 23, 2003, featuring an ensemble cast, which has included: Mark Harmon, Sasha Alexander, Michael Weatherly, Pauley Perrette, David McCallum, Sean Murray, Cote de Pablo, Lauren Holly, Rocky Carroll, Brian Dietzen, Emily Wickersham, Wilmer Valderrama, Jennifer Esposito, Duane Henry, Maria Bello, Diona Reasonover, K...