Atypical lipomatous tumor / well differentiated liposarcoma
2023年5月5日 · Terminology. Use of the terminology atypical lipomatous tumor (ALT) and well differentiated liposarcoma (WDL) is based on a tumor's location in the body and primarily relates to resectability. Tumors are morphologically and genetically identical, with the variation in terminology intended to avoid both undertreatment and overtreatment.
Pathology Outlines - Pleomorphic liposarcoma
2022年5月11日 · Pleomorphic rhabdomyosarcoma: High grade sarcoma with prominent pleomorphism that may resemble areas of pleomorphic liposarcoma. However, usually shows evidence of rhabdomyoblastic differentiation rather than adipocytic differentiation. Positive for myogenic markers, such as MyoD1, myogenin and desmin.
Pathology Outlines - Grading
2022年1月14日 · By FNCLCC, well differentiated liposarcoma / atypical lipomatous tumor by definition are grade 1 and dedifferentiated liposarcoma may be grade 2 or 3 There remains controversy over whether nonlipogenic areas with low grade features should be classified as low grade dedifferentiation or cellular well differentiated liposarcoma ( Am J Surg Pathol ...
Pathology Outlines - Spindle cell / pleomorphic lipoma
2021年9月14日 · Microscopic (histologic) description. Triad of mature adipocytes, bland spindle cells and hyalinized rope-like collagen fibers. Multinucleated stromal giant cells and floret cells in pleomorphic lipoma. Myxoid background with mast cells frequent. Short and stubby spindle cells show occasional palisading.
Pathology Outlines - MDM2
2020年11月25日 · MDM2 amplified on supernumerary ring or marker chromosomes in many tumors, leading to suppression of p53. Common in atypical lipomatous tumor / well differentiated liposarcoma and dedifferentiated liposarcoma; often used to distinguish these entities from mimickers. Distinguish low grade osteosarcoma and parosteal osteosarcoma (positive) from ...
Pathology Outlines - Chondroid lipoma
2022年4月27日 · Myxoid liposarcoma: Spindle to stellate cells with myxoid stroma Plexiform vasculature Lipoblasts of signet type are typically present Round cell component shows uniform round cells with moderate pleomorphism and scant cytoplasm t(12;16), t(12;22) translocation Extraskeletal myxoid chondrosarcoma: Larger infiltrative mass
Pathology Outlines - Low grade fibromyxoid sarcoma
2021年8月23日 · Microscopic (histologic) description. Low to moderately cellular, bland fusiform or spindled cells with focal to diffuse whirling in heavily collagenized stroma with abrupt transition to myxoid areas. 45% have epithelioid areas. 40% contain poorly formed but large collagen rosettes. Often infiltrates adjacent skeletal muscle.
Pathology Outlines - Soft tissue
A-E: alveolar rhabdomyosarcoma alveolar soft part sarcoma anastomosing hemangioma angiofibroma of soft tissue angioleiomyoma angiolipoma angiomatoid fibrous histiocytoma angiomyofibroblastoma angiosarcoma arteriovenous malformation atypical lipomatous tumor / well differentiated liposarcoma atypical spindle cell / pleomorphic lipomatous tumor ...
Pathology Outlines - Synovial sarcoma
2021年9月13日 · Synovial sarcoma, monophasic, FNCLCC grade 2 (see comment) Comment: The tumor is composed of fascicles of bland spindle cells with sparse cytoplasm and relatively uniform, ovoid hyperchromatic nuclei and inconspicuous nucleoli. The stroma contains strands of wiry collagen. Mitoses are sparse (2 mitoses/10 high power fields).
Pathology Outlines - Embryonal rhabdomyosarcoma
2022年3月3日 · Myxoid liposarcoma (MLS): Although MLS typically is very easy to distinguish from ERMS, it can have a very similar background matrix that is loose and lightly basophilic Cells can focally resemble one another as well Look for signet ring lipoblasts in MLS, more bland histology and more uniformity when compared to ERMS