The myosin superfamily is a large and diverse protein family, and its members, which are grouped into many classes (Foth et al., 2006; Odronitz and Kollmar, 2007), are involved in a number of cellular pathways (Krendel and Mooseker, 2005; Woolner and Bement, 2009). We first describe the basics of myosin mechanoenzymology and motility.

Myosins belong to a superfamily of proteins that contain three functional domains (see Myosin: Fundamental Properties and Structure and Myosin Work and Motility: Mechanism): (1) a motor domain, with a highly conserved core structure comprising the ATP and actin-binding sites, (2) a neck domain (also called lever arm), consisting of an α-helical ...

Finally, we infer an intricate evolutionary history of the myosin gene family, including multiple lineage-specific expansions (such as the myosin III-like group in the choanoflagellate lineage), domain diversifications (specially in holozoans), secondary losses (in metamonads and rhodophytes), and convergences (e.g., in the fungal and metazoan ...

Myosins (/ ˈmaɪəsɪn, - oʊ -/ [1][2]) are a family of motor proteins (though most often protein complexes) best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP -dependent and responsible for actin -based motility.

2012年4月1日 · The myosin superfamily is a large and diverse protein family, and its members, which are grouped into many classes (Foth et al., 2006; Odronitz and Kollmar, 2007), are involved in a number of cellular pathways (Krendel and Mooseker, 2005; Woolner and Bement, 2009). We first describe the basics of myosin mechanoenzymology and motility.

2000年10月1日 · This unrooted phylogenetic tree of the myosin superfamily (see insert) is derived from an alignment of 139 members of the myosin superfamily. The alignment compared the core motor domains (equivalent to residues 88-780 of chicken skeletal myosin II) of each myosin, using distance matrix analysis performed with the Clustal-W package.

The myosin superfamily is a versatile group of molecular motors involved in the transport of specific biomolecules, vesicles and organelles in eukaryotic cells. The processivity of myosins along an actin filament and transport of intracellular ...

2011年9月30日 · Myosins comprise a family of ATP-dependent motor proteins that are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. Recent phylogenetic analysis places myosins into 35 …

The first part of this review focuses on how myosins convert the chemical energy of ATP hydrolysis into mechanical movement, followed by a description of existing therapeutic approaches to target human β-cardiac myosin. The next section focuses on the possibility of targeting nonmuscle members of the human myosin family for several diseases.

Myosin is a highly conserved, ubiquitous protein found in all eukaryotic cells, where it provides the motor function for diverse movements such as cytokinesis, phagocytosis, and muscle contraction. All myosins contain an amino-terminal motor/head domain and a carboxy-terminal tail domain.