2022年5月9日 · Damaged mitochondria need to be selectively removed through mitochondrial autophagy (mitophagy), the process of which is controlled by nuclear coding proteins [13].

This graphic review gives a broad summary of autophagy and discusses examples where autophagy is important in controlling protein degradation. In addition we highlight how autophagy and mitophagy are involved in the cellular responses to reactive species and …

Autophagic substrates are identified by sequestosome 1 (SQSTM1) binding to misfolded proteins (brown clouds) with ubiquitin tags (Ub), while mitochondria are identified by unique ubiquitin binding and complex kinase-dependent activation of parkin RBR E3 ubiquitin protein ligase (PRKN) and PTEN-induced kinase 1 (PINK1) (purple boxes).

2023年9月13日 · Mitophagy is a selective form of macroautophagy (hereafter "autophagy") that cells use to degrade mitochondria. During mitophagy, mitochondria are selectively sequestered within double-membrane vesicles called autophagosomes that deliver their mitochondrial cargo to lysosomes for degradation.

2023年8月16日 · In this review, we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination, how mitophagy maintains mitochondrial homeostasis at the system levels and organ, and what...

2018年8月28日 · We consider the contributions of mitophagy in physiological and pathological contexts and discuss emerging findings, highlighting the potential value of mitophagy modulation in therapeutic...

2013年1月1日 · This graphic review gives a broad summary of autophagy and discusses examples where autophagy is important in controlling protein degradation. In addition we highlight how autophagy and mitophagy are involved in the cellular responses to reactive species and mitochondrial dysfunction.

2021年1月13日 · Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control.

Mitophagy is a selective form of macro-autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by eliminating dysfunctional mitochondria and reducing mitochondrial mass as …

2024年3月1日 · Mitochondrial autophagy (Mitophagy) is a specific form of cellular autophagy (Lu et al., 2023). Mitochondria can respond to external stresses by selectively removing excess mitochondria or abnormal mitochondrial function, which ensures mitochondrial quality and maintains mitochondrial function (Pickles et al., 2018).