MG132 - Wikipedia
MG132 is a potent, reversible, and cell-permeable proteasome inhibitor [1] (K i = 4 nM). It belongs to the class of synthetic peptide aldehydes. [2][3] It reduces the degradation of ubiquitin …
MG-132 (MG132) | Proteasome Inhibitor - MedChemExpress
2016年8月31日 · MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC 50 s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of …
MG-132 | Cell Signaling Technology
MG-132 is a potent proteasome and calpain inhibitor. Research studies have shown that MG-132 prevents degradation of the proteasome substrates SucLLVY-MCA and ZLLL-MCA with an …
MG-132 - MilliporeSigma
Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. …
MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome. This potent inhibitor is used as a tool for disrupting the proteasome …
MG-132: peptide aldehyde - 26S proteasome inhibitor, …
MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome. The 26S proteasome is a large protease complex that degrades …
Prolonged treatment with the proteasome inhibitor MG-132 …
2022年4月6日 · MG-132 (Merck, Kenilworth, NJ, USA Cat. # 474790) used at a final concentration of 2.5 µM is a potent and selective, cell permeable, peptidyl-aldehyde type …
Induction of autophagy by the MG‑132 proteasome inhibitor is ... - PubMed
The proteasome inhibitor, MG‑132, was used to induce autophagy in MCF‑7 cells, and 3‑methyladenine (3‑MA) and salubrinal were used to inhibit autophagy and ER stress, …
MG132-mediated inhibition of the ubiquitin–proteasome pathway ...
We found that MG132 could effectively reverse skeletal muscle atrophy and inhibit tumor growth, accompanied by downregulation of the NF-κB/ubiquitin–proteasome pathway. MG132 is a …
Prolonged treatment with the proteasome inhibitor MG-132 …
Rat pheochromocytoma (PC12) cells were treated with the proteasome inhibitor MG-132 and morphological changes were recorded. Initially, neuronal differentiation was induced but after …