Methylene Blue and the Risk of Serotonin Toxicity
2015年4月9日 · Methylene blue, unlike indigo carmine, is a potent MAO inhibitor and when combined with a variety of medications with serotonergic activity, may contribute to serious sequelae secondary to serotonin toxicity.
Serotonin syndrome (serotonin toxicity) - UpToDate
2024年9月12日 · Serotonin syndrome (ie, serotonin toxicity) is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is seen with therapeutic medication use, inadvertent interactions …
CNS reactions possible when methylene blue is given to …
[07-26-2011] The U.S. Food and Drug Administration (FDA) has received reports of serious central nervous system (CNS) reactions when the drug methylene blue is given to patients taking...
Methylene blue and serotonin toxicity: inhibition of monoamine oxidase ...
Monoamine oxidase inhibitors (MAOI) are known to cause serotonin toxicity (ST) when administered with selective serotonin reuptake inhibitors (SSRI). Methylene blue (methylthionium chloride, MB), a redox dye in clinical use, has been reported to precipitate ST in …
The role of methylene blue in serotonin syndrome: a systematic …
Abstract. Background: A recent series of case reports has demonstrated a significant, previously unrecognized drug interaction between serotonin reuptake inhibitors (SRIs) and methylene blue (MB). Objective: The authors review the case reports and clinical audits relevant to this interaction and consider the diagnosis of serotonin syndrome in ...
Methylene blue: a controversial diagnostic acid and medication?
MB induced serotoninergic toxicity clinically manifests as neuromuscular hyperactivity. This review aims to summarize the current understanding concerning the indications for MB administration and define the potential adverse effects of MB. Keywords: serotonin syndrome, neurotoxicity, methemoglobinemia, vasoplegic syndrome, methylene blue.
Serotonin syndrome: Preventing, recognizing, and treating it
2016年11月1日 · Drugs that decrease serotonin breakdown include monoamine oxidase inhibitors (MAOIs), linezolid, 6 methylene blue, procarbazine, and Syrian rue.
Serotonin Syndrome: Pathophysiology, Clinical Features, …
Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral (PNS) and central nervous systems (CNS).
The Role of Methylene Blue in Serotonin Syndrome: A
2010年5月1日 · Our review demonstrates a recurring and potentially severe syndrome in patients who are given methylene blue while taking SRIs. There is clinical and pharmacological evidence to support a diagnosis of serotonin syndrome.
Serotonin Syndrome/Serotonin Toxicity - PMC - National …
This review of serotonin syndrome or serotonin toxicity covers the years 2014 to 2019, including information on pathophysiology, etiology, and diagnosis, 3 criteria for diagnosing serotonin syndrome, and criteria for neuroleptic malignant syndrome.