Melphalan Hydrochloride | C13H19Cl3N2O2 | CID 9927978
Melphalan Hydrochloride is a bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA.
Melphalan | C13H18Cl2N2O2 | CID 460612 - PubChem
Jan 12, 2016 · Melphalan is a phenylalanine derivative comprising L-phenylalanine having [bis (2-chloroethyl)amino group at the 4-position on the phenyl ring. It has a role as an antineoplastic agent, a carcinogenic agent, an alkylating agent, an immunosuppressive agent and a …
Melphalan - Wikipedia
Melphalan, sold under the brand name Alkeran among others, is a chemotherapy medication used to treat multiple myeloma; malignant lymphoma; lymphoblastic and myeloblastic leukemia; childhood neuroblastoma; ovarian cancer; mammary adenocarcinoma; and uveal melanoma.
Melphalan Hydrochloride | C13H19Cl3N2O2 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Melphalan Hydrochloride, 3223-07-2
Melphalan hydrochloride - DrugBank Online
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. 7 It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. 4,5 Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. 7 It is also used for high-conditioning before hematopoietic stem ...
MELPHALAN - Pharmaceuticals - NCBI Bookshelf
Melphalan is an antineoplastic agent that acts as a bifunctional alkylating agent. It is used in the treatment of multiple myeloma, advanced ovarian adenocarcinoma, early and advanced breast cancer, childhood neuroblastoma, and polycythaemia vera.
Melphalan Hydrochloride for Injection(For Intravenous Infusion) - DailyMed
Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine. The molecular formula is C 13 H 18 Cl 2 N 2 O 2 and the molecular weight is 305.20. The structural formula is:
Chemical modification of melphalan as a key to improving
Mar 11, 2020 · The structure of melphalan molecule is notable for the presence of two modifiable functional groups, amino and carboxyl group. Systemic modification of both of these groups gives the...
Melphalan: Uses, Interactions, Mechanism of Action - DrugBank …
Melphalan is an alkylating agent used to treat multiple myeloma, ovarian carcinoma, uveal melanoma with unresectable hepatic metastases, and for high-dose conditioning before hematopoietic stem cell transplant in patients.
Melphalan HCl | Drug Information, Uses, Side Effects, Chemistry ...
Melphalan Hydrochloride is a bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures.