Mucin short variant S1 - Wikipedia
Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. [3] Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain.
Mucin-1 - Wikipedia
Mucin-1 (MUC-1) is a heterodimer transmembrane protein of the mucin family encoded in humans by the MUC1 gene. [3][4][5] It is cleaved into two chains: mucin-1 subunit alpha (MUC1-NT; MUC1-alpha) and mucin-1 subunit beta (MUC-CT; MUC1-beta).
MUC1 Gene - GeneCards | MUC1 Protein | MUC1 Antibody
4 天之前 · MUC1 (Mucin 1, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC1 include Tubulointerstitial Kidney Disease, Autosomal Dominant, 2 and Muc1-Related Autosomal Dominant Tubulointerstitial Kidney Disease. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.
MUC1 gene - MedlinePlus
The MUC1 gene provides instructions for making a protein called mucin 1. This protein is one of several mucin proteins that make up mucus, a slippery substance that lubricates and protects the lining of the airways, digestive system, reproductive system, and other organs and tissues.
MUC1: Structure, Function, and Clinic Application in Epithelial …
2021年6月18日 · This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in …
Research progress of MUC1 in genitourinary cancers
2024年11月3日 · MUC1 is a highly glycosylated transmembrane protein with a high molecular weight. It plays a role in lubricating and protecting mucosal epithelium, participates in epithelial cell renewal and differentiation, and regulates cell …
MUC1 (CD227): a multi-tasked molecule | Cellular and Molecular …
Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in …
Differential expression of the human mucin genes MUC1 to MUC5 …
1993年11月1日 · It is now known that several distinct genes encode the apomucins. MUC1 (Gendler et al., 1987; Lan et al., 1990) encodes a transmembrane mucin-like glycoprotein expressed in many epithelial cell types.
The Role of MUC1 in Renal Cell Carcinoma - MDPI
2024年3月7日 · MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. When epithelial cells lose their tight connections, due to the loss of polarity, the mucins become dispersed on both sides of the epithelial membrane, leading to an abnormal mucin interactome with the membrane.
MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function …
2017年11月29日 · MUC1 is a membrane-bound mucin expressed on the apical surfaces of most mucosal epithelial cells. In normal lung epithelia, MUC1 is a binding site for Pseudomonas aeruginosa, an opportunistic human pathogen of great clinical importance.