2021年2月15日 · Liver sinusoidal endothelial cells (LSECs) form the vascular wall of the hepatic microcirculatory system, the hepatic sinusoid, and exhibit unique phenotypic characteristics, including...

Main mechanisms leading to microvascular thrombosis and parenchymal extinction in liver cirrhosis. In the presence of low-grade chronic inflammation, liver sinusoid endothelial cells acquire vascular endothelial cells phenotype, upregulating the production and release of VWF in the form of HMWVWF multimers and FVIII.

2018年5月29日 · In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis...

Results: Expression of the neutrophil chemoattractant CXCL1 was up-regulated in primary LSECs exposed to mechanical stretch, compared with unexposed cells. Intravital imaging of livers in control mice revealed sinusoidal complexes of neutrophils …

As the most abundant non-parenchymal hepatic cell population, liver sinusoidal endothelial cells (LSECs) are stabilizers that maintain the intrahepatic environment. Notably, LSECs dysfunction appears to be implicated in the progression of liver fibrosis via numerous mechanisms.

2019年7月1日 · Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes.

Liver sinusoidal endothelial cells (LSECs) subjected to cyclic stretch secrete the neutrophil chemoattractant CXCL1. CH is characterized by passive hepatic congestion and sinusoidal dilatation which imparts mechanical stretch on LSECs.

2017年1月1日 · Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells representing the interface between blood cells on the one side and hepatocytes and hepatic stellate cells on the other side.

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike other capillaries, they lack an organized basement membrane and have cytoplasm that is penetrated by open fenestrae, making the hepatic microvascular endothelium discontinuous.

2025年2月3日 · Liver sinusoidal endothelial cells (LSECs), with their unique morphology and function, have garnered increasing attention in chronic liver disease research. This review summarizes the critical roles of LSECs under physiological conditions and in two representative chronic liver diseases: metabolic dysfunction-associated steatotic liver disease (MASLD) and liver cancer. Under physiological ...