Untreated adult nonalcoholic fatty liver disease (NAFLD) is characterized by absent or mild portal chronic inflammation (CI); in the portal-based pediatric pattern of NAFLD, portal CI may be a predominant component. This study was undertaken to correlate clinical features with portal CI in the subjects enrolled in the NASH CRN.

The key histologic findings of the portal pattern include portal/periportal inflammation and fibrosis. The inflammation is mononuclear, but is predominantly lymphocytic (Figure 3A,3B). In some cases, lymphoid aggregates may also be seen.

All liver biopsies were reviewed by one pathologist to evaluate various histological features. Results: More than a mild degree of portal inflammation was found in 47% of AFLD compared with 30% in NAFLD subgroup. A higher degree of portal inflammation in AFLD was associated with a higher mean corpuscular volume, gamma glutamyl transferase (GGT ...

2022年10月1日 · Histological parameters of portal inflammation, portal plasma cells, interface hepatitis and bile duct damage were evaluated in 10 portal tracts or 10 septal areas in each liver biopsy.

2016年6月25日 · Portal inflammation is probably the most commonly observed pattern of liver injury (Fig. 3.1). Two major and common disease processes – chronic viral hepatitis and autoimmune hepatitis – are characterized by prominent portal mononuclear inflammation, and several other diseases feature minor portal inflammation in addition to more ...

The portal infiltrate was characterized by immunostaining NAFLD liver biopsy sections (n = 33) for broad leukocyte subset markers (CD68, CD3, CD8, CD4, CD20, and neutrophil elastase) and selected inflammatory markers (matrix metalloproteinase 9 and interleukin [IL]-17).

2024年9月7日 · A consistent feature of chronic liver diseases and the hallmark of pathologic repair is the so-called “ductular reaction.” This is a histologic abnormality characterized by an expansion of dysmorphic cholangiocytes inside and around portal spaces infiltrated by inflammatory, mesenchymal, and vascular cells.

Collectively, commensal bacteria induce Marco + immunosuppressive macrophages, which consequently limit excessive inflammation at the gateway of the liver. Failure of this self-limiting system promotes hepatic inflammatory disorders such as PSC and NASH.

Chronic inflammation leads to the activation of hepatic stellate cells that undergo trans-differentiation to become myofibroblasts, the main extra-cellular matrix producing cells in the liver; over time increased extra-cellular matrix production results in the formation of liver fibrosis.

2023年1月1日 · Liver biopsies may show features of large duct obstruction, with bilirubinostasis, mild portal inflammation, and portal edema. In small portal tracts, ischemic bile ducts often show cytoplasmic vacuolization, nuclear pyknosis, and small duct profiles, similar to PSC.