The role of lipoxygenases in pathophysiology; new insights and …
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. LOX enzymes are expressed in immune, epithelial, and tumor cells that display a variety of physiological functions, including inflammation, skin disorder, and tumorigenesis.
Plant Lipoxygenases and Their Role in Plant Physiology
2020年3月13日 · Lipoxygenases are a ubiquitous family of non-heme iron enzymes widely distributed in plants, initiate hydroperoxidation of polyunsaturated fatty acids containing cis, cis -1,4-pentadiene moieties, and produce phytooxylipins.
Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition …
In this review the diversity of lipoxygenase expression will be highlighted and the several facets of lipoxygenase function considered, concluding with a discussion of issues related to the acquisition of substrate in a cellular environment.
Structural considerations on lipoxygenase function, inhibition …
2020年11月1日 · Lipoxygenases (LOX) are non-heme iron-containing enzymes that catalyze regio- and stereo-selective dioxygenation of polyunsaturated fatty acids (PUFA).
Structural and mechanistic insights into 5-lipoxygenase ... - Nature
2020年5月11日 · The enzyme 5-lipoxygenase (5-LOX) initiates the biosynthesis of leukotrienes (LTs), potent mediators of the inflammatory response, with a two-step reaction that starts with oxygenation of the...
Lipoxygenase - an overview | ScienceDirect Topics
Lipoxygenases are iron-containing oxidoreductase enzymes that catalyze the deoxygenation of polyunsaturated fatty acids containing a cis, cis-1,4-pentadiene-conjugated double bond system such as linoleate and linolenate to yield hydroperoxides. From: Trends in Food Science & Technology, 2020.
Lipoxygenase - an overview | ScienceDirect Topics
2011年1月13日 · Lipoxygenase is a dioxygenase which recognizes the 1-cis, 4- cis -pentadiene structure of polyunsaturated fatty acids, and produces hydroperoxy acids with a conjugated diene. In mammalian tissues there are several different lipoxygenases distinguished by the oxygenation site in the unsaturated fatty acid molecules.
Mammalian lipoxygenases and their biological relevance
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance.
Lipoxygenase - SpringerLink
Lipoxygenase (linoleate:oxygen oxidoreductase, EC 1.3.11.12) is a dioxygenase that catalyzes the oxygenation of polyunsaturated fatty acids (LH) containing a cis, cis -1,4-pentadiene system to hydroperoxides (LOOH). The enzyme exists in multiple forms, three in …
Regulation of Tissue Inflammation by 12-Lipoxygenases - PMC
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates.
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