Lentivirus - Wikipedia
Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. [2] . The genus includes the human immunodeficiency virus (HIV), which causes AIDS.
Lentiviral vector in gene therapy - Wikipedia
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a family of viruses that are responsible for diseases like AIDS, which infect by inserting DNA into their host cells' genome. [1]
Lentiviral Guide - Addgene
Lentiviral tropism is determined by the ability of the viral envelope protein to interact with receptors at the host cell surface. The VSV-G envelope protein is commonly used in lentiviral particle production because it confers broad tropism over a range of species and cell types.
The Revival of Lentiviral Vectors - Nature
Current lentiviral vector systems (the third generation) generate virus particles using four plasmids and a producer cell line. The rationale behind four plasmids is to enhance safety, as...
Lentivirus (lente-, latin for “slow”) is a group of retroviruses characterized for a long incubation period. They are classified into five serogroups according to the vertebrate hosts they infect: bovine, equine, feline, ovine/caprine and primate. Some examples of lentiviruses are Human (HIV), Simian (SIV) and Feline (FIV) Immunodeficiency Viruses.
The Inside Out of Lentiviral Vectors - PMC - PubMed Central (PMC)
Lentiviral vectors bears an obvious advantage over other retroviral vectors in that they offer the possibility to efficiently target non-dividing and differentiated cells, such as DCs or neurons. As such, these vectors are of extreme interest for a multitude of gene therapy applications.
Clinical use of lentiviral vectors | Leukemia - Nature
2018年3月22日 · Third-generation, self-inactivating lentiviral vectors have recently been used in multiple clinical trials to introduce genes into hematopoietic stem cells to correct primary immunodeficiencies...
Clinical use of lentiviral vectors - PubMed
2020年7月18日 · Third-generation, self-inactivating lentiviral vectors have recently been used in multiple clinical trials to introduce genes into hematopoietic stem cells to correct primary immunodeficiencies and hemoglobinopathies.
Lentiviral vectors, two decades later | Science - AAAS
2016年9月9日 · Lentiviruses, in contrast to other types of retroviruses used to develop vectors, had the ability to infect, replicate, and integrate in some nondividing cells, such as macrophages (2). However, there were substantial challenges in developing gene therapy vectors from HIV.
The very stable lentiviral vector - Cell Press
2024年3月14日 · Lentiviral vectors (LVs) have emerged within the last 20 years as a leading gene therapy vehicle. 1 Although LVs are favored for their ability to permanently deliver a desired payload to nearly any human target cell, clinical-grade production of LVs is difficult and expensive, often with year-long lead times. This stifles the innovation of ...