Lactate metabolism in human health and disease
2022年9月1日 · Lactic acid production and clearance. The production of lactate as fuel increases when the demand for oxygen and ATP exceeds the cellular supply, such as during strenuous exercise and infection...
Poly(lactic acid) modifications - ScienceDirect
2010年3月1日 · Lactic acid, the monomeric building block of PLA, is produced by converting sugar or starch obtained from vegetable sources (e.g., corn, wheat, or rice) using either bacterial fermentation or a petrochemical route. Lactic acid exists as two optical isomers, l - …
A Review: Research Progress in Modification of Poly (Lactic Acid) …
In this context, poly (lactic acid) has shown a unique combination of properties such as nontoxicity, biodegradability, biocompatibility, and good workability. However, examples of its known drawbacks include poor tensile strength, low elongation at break, poor thermal properties, and low crystallization rate.
Lactylation: the novel histone modification influence on gene ...
2024年5月29日 · Protein lactylation is a new modification of posttranslational modification related to lactic acid which influences the physiological and pathological processes by regulating the gene expression and protein function.
Recent advances in modified poly (lactic acid) as tissue …
2023年3月20日 · Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.
Lactic acid induces transcriptional repression of macrophage ...
2024年2月27日 · We found that lactic acid serves as a primary fuel source to promote histone H3K27 acetylation, which allows the expression of immunosuppressive gene program including Nr4a1. Consequently, macrophage pro-inflammatory function was transcriptionally repressed.
Carbon Nitride Grafting Modification of Poly(lactic acid) to …
2023年9月15日 · To enhance the interfacial interaction with the PLA matrix, a silane-coupling agent (γ-methacryloxypropyl trimethoxysilane, KH570) is chemically grafted onto the CN surface after controlled oxidation with nitric acid and hydrogen peroxide.
Graphene Oxide-Enhanced and Dynamically Crosslinked Bio
2024年5月28日 · In the present study, a bio-elastomeric material of epoxidized soybean oil (ESO) crosslinked with sebacic acid (SA) and enhanced by graphene oxide (GO) nanoparticles (NPs) was employed to toughen PLA with the purpose of simultaneously preserving strength and achieving additional functions.
Full article: Lactic acid bacteria derived extracellular vesicles ...
Lactic acid bacteria (LAB) constitute a diverse taxonomic assemblage proficient in fermenting carbohydrates to produce lactic acid. Citation 1 Primarily classified within the phyla Firmicutes, Actinobacteria, and Bacteroidetes, this group encompasses a broad spectrum of genera, totaling approximately 45. LAB exhibit a ubiquitous presence across ...
The Development of Poly(lactic acid) (PLA)-Based Blends and
2024年9月17日 · The presented review article discusses the current strategies to optimize the balance of the key features such as stiffness, toughness, and heat resistance of PLA-based blends.