The kinesin dimer (red) attaches to, and moves along, microtubules (blue and green). Animation of kinesin "walking" on a microtubule. A kinesin is a protein complex belonging to a class of motor proteins found in eukaryotic cells.

驱动蛋白（英語： Kinesin ）是一类蛋白质超级家族，属于分子马达的一种，其成员代表驱动蛋白-1（ Kinesin-1 ）在1985年被发现。 驱动蛋白是由单体组成的多聚体，其“头部”具有 ATP酶 活性 [ 1 ] ，能通过水解 ATP 获得能量，改变构型，进行运动。

驱动蛋白（Kinesin）是一条长80nm的杆状结构，头部一端有两个成球状的马达结构域，另一端是重链(kinesin heavy chain，KHC）和轻链(kinesin light chain，KLC）组成的扇形尾端，中间是重链组成的杆状区。

与微管结合而起运输作用的 马达蛋白 有两大类：驱动蛋白kinesin， 动力蛋白 dynein，两者均需ATP提供能量。

2023年7月19日 · Kinesin plays an essential role in vesicle and organelle transport. It transfers vesicles to the presynaptic axonal regions in order for the mediation of synaptic transmission to occur.

Most kinesins contain: (1) a catalytic domain (also known as a motor or head domain) responsible for nucleotide catalysis, microtubule binding, and force production, (2) a central α-helical stalk domain involved in coiled–coil interactions to organize the motor into higher order oligomers (e.g., dimers, tetramers), and (3) a tail domain ...

2024年10月11日 · This Review focuses on recent structural and functional studies that reveal how members of the kinesin superfamily use the energy of ATP hydrolysis to transport cargoes, depolymerize microtubules...

2009年10月1日 · Kinesin superfamily proteins (also known as KIFs) are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs.

Kinesin was discovered in 1985 – 25 years ago – based on its motility in cytoplasm extruded from the giant axon of the squid (Allen et al., 1982; Brady et al., 1982; Vale et al., 1985). The purified protein, now known as kinesin-1, consisted of two heavy chains with motor activity that were associated with two light chains, which mediate ...

Kinesin is eukaryotic-conserved motor proteins that move along MTs with ATP hydrolysis. Each kinesin has a motor domain, which converts the energy ATP hydrolysis into mechanical work and which defines a protein as a kinesin. Kinesins contain many other domains, which are responsible for many other activities such as cargo binding or regulation.