In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

Kinase, an enzyme that adds phosphate groups to other molecules. A large number of kinases exist, the human genome alone containing hundreds of kinase-encoding genes. Included among kinase targets for phosphorylation are proteins, lipids, and nucleic acids.

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

In this Special Issue “Protein Kinases: Function, Substrates, and Implication in Diseases”, we collected seven review papers and five original research articles, focused on new findings, recent advances and future development in the protein kinase field.

2023年12月1日 · What is a Kinase and How Does it Work in the Cell. Kinases are enzymes that help regulate cells of all living organisms by controlling signal transduction pathways. In essence, they act as a catalyst to “switch on/off” various cellular functions including metabolism and growth.

Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ‘the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery.

2022年3月3日 · Regulation and Function of Protein Kinase. There are about 500 protein kinase encoding genes in the human genome which represents 2% of all the human genes. Kinase is the name given to an enzyme that adds a phosphate group (PO 4 3-) to other biomolecules such as protein, lipid, or nucleotides. This type of addition of a phosphate group is ...

2023年6月13日 · Prominent examples include the mitogen-activated protein kinase kinase (MAP2K or MEK) family and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). Protein kinases can be further classified according to their function.

2017年11月23日 · Kinase and phosphatase are two types of enzymes that consist of opposite actions on the phosphate groups. Kinases are a type of phosphotransferases that add phosphate groups to the substrate from ATP molecules.

2025年2月6日 · Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging.

Protein kinases and phosphatases are enzymes catalysing the transfer of phosphate between their substrates. A protein kinase catalyses the transfer of γ-phosphate from ATP (or GTP) to its protein substrates while a protein phosphatase catalyses the transfer of the phosphate from a phosphoprotein to a water molecule. Even though both groups of ...

A kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. From: The World’s Health Care Crisis, 2011

2010年9月10日 · The kinase reaction Protein Kinases bind substrate proteins and ATP and transfer a phosphate group from ATP to amino acids with free hydroxyl (-OH) groups ( serine , threonine or tyrosine ). The products are the phospho-protein and ADP .

kinase. Listen to pronunciation (KY-nays) A type of enzyme (a protein that speeds up chemical reactions in the body) that adds chemicals called phosphates to other molecules, such as sugars or proteins. This may cause other molecules in the cell to become either active or inactive. Kinases are a part of many cell processes.

Protein kinases (PKs), belonging to the kinase family, are a kind of phosphotransferases responsible for the transfer of the γ-phosphate from ATP to the specific amino acid residues of the substrate proteins.

Kinases are particularly prominent in signal transduction and co-ordination of complex functions such as the cell cycle. The diversity of essential functions mediated by kinases is shown by the conservation of some 50 distinct kinase families between yeast, …

Susan Taylor gives an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily.

A kinase is an enzyme that catalyzes the transfer of a phosphate group from a high-energy molecule, such as ATP, to a specific substrate, which can include proteins, lipids, or carbohydrates.

A kinase is an enzyme that plays a crucial role in cell signaling pathways by adding a phosphate group to other molecules, typically proteins. This process, known as phosphorylation, can activate or deactivate target proteins, regulating various cellular processes.

Protein kinase is a family of enzymes that catalyzes the transfer of a phosphate group from ATP to a protein or peptide substrate.