Chapter 8 The Kell blood group - National Center for …
The Kell blood group system is complex and contains many antigens that are highly immunogenic. These antigens are the third most potent, after those of the ABO and Rh blood groups, at triggering an immune reaction.
Hemolytic disease of the newborn (anti-Kell) - Wikipedia
Hemolytic disease of the newborn (anti-Kell 1) is caused by a mismatch between the Kell antigens of the mother and fetus. About 91% of the population are Kell 1 negative and about 9% are Kell 1 positive.
Mother with anti-Kell antibodies. What are the …
What are the recommendations for managing patients with anti Kell antibodies? The American College of Obstetricians and Gynecologists recommends determination of the father’s red blood cell antigen status as the first step.
Isoimmunization - USF Health
What causes isoimmunization? When the proteins on the surface of the baby's red blood cells are different from the mother's protein, the mother's immune system produces antibodies that fight and destroy the baby's cells.
Management of Alloimmunization During Pregnancy - ACOG
ABSTRACT: When any fetal blood group factor inherited from the father is not possessed by the mother, antepartum or intrapartum fetal–maternal bleeding may stimulate an immune reaction in the mother. Maternal immune reactions also can occur from blood product transfusion. The formation of maternal antibodies, or “alloimmunization,” may lead to various degrees of …
Hemolytic disease of the newborn (HDN) or Alloimmunization
Hemolytic Disease of the Newborn (HDN) is also known by other names, including alloimmunization, isoimmunization, blood incompatibility, or blood sensitization. It can range from very mild, with minimal to no fetal effects, to very severe requiring fetal therapy.
Alloimmune hemolytic disease of the newborn: Postnatal ... - UpToDate
2024年7月15日 · Alloimmune HDN primarily involves the major blood groups of Rhesus (Rh), A, B, AB, and O, although minor blood group incompatibilities (Kell, Duffy, MNS, P, and Diego systems) can also result in significant disease . (See "Red blood cell antigens and antibodies".)
Hemolytic disease of the fetus and newborn: managing the mother, fetus ...
2015年12月5日 · Diagnostic laboratory technologies for the fetus and neonate with isoimmunization,
Management of pregnancies with anti-K alloantibodies and the …
2024年8月26日 · Anti-KEL1 antigen (also referred to as anti-Kell, or anti-K) alloimmunisation is the second most common cause of severe haemolytic disease of the fetus and newborn, after anti-rhesus D antigen, and can cause substantial fetal morbidity and mortality.
Predicting anti-Kell-mediated hemolytic disease of the fetus and ...
2018年5月1日 · Without early detection and treatment, anti-Kell-mediated hemolytic disease of the fetus and newborn may result in progressive fetal anemia, fetal hydrops, asphyxia, and perinatal death.