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Engineering of anti-human interleukin-4 receptor alpha ... - Nature
2019年5月23日 · Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (TH2)-mediated...
Dupilumab (Dupixent): An Interleukin-4 Receptor Antagonist for …
Dupilumab is an interleukin-4 (IL-4) receptor alpha antagonist. It is a human monoclonal antibody of the immunoglobulin G4 subclass that inhibits IL-4 and interleukin-13 (IL-13) signaling by specifically binding to the IL-4 receptor alpha subunit, which is shared by the IL-4 and IL-13 receptor complexes.
Interleukin-4 receptor - Wikipedia
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells , the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells .
Frontiers | Interleukin-4 Receptor Alpha: From Innate to …
2017年11月9日 · In this review, we focus on the cell-specific requirements of the IL-4Rα chain signaling on crucial cells mediating innate and adaptive immunity to CL, relating primarily to L. major infection in mouse models. Interleukin-4 plays a critical role in initiating and regulating Th2-type immune responses (14).
Engineering of anti-human interleukin-4 receptor alpha ... - PubMed
2019年5月23日 · Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (T H 2)-mediated allergic diseases such as asthma and atopic dermatitis. Here we isolated anti-human IL-4Rα antagonistic …
Structure, binding, and antagonists in the IL-4/IL-13 receptor …
2002年11月11日 · Interleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-4Rα. Receptor sharing by these two cytokines is the molecular basis for their overlapping biological functions.
Design of human interleukin-4 antagonists inhibiting interleukin-4 ...
1994年10月15日 · These results indicate that efficient interleukin-4 antagonists can be designed on the basis of a sequential two-step activation model. In addition, the experiments indicate the functional participation of the interleukin-4 receptor alpha …
IL-4 receptor alpha is an important modulator of IL-4 and IL-13 ...
2006年6月15日 · Based on the different mechanisms of binding and stabilization of the IL-4R and IL-13R complexes, we compared the effects of shIL-4Ralpha and an IL-4 double mutein (R121D/Y124D, IL-4R antagonist) on IL-4- and IL-13-mediated responses.
Engineering of anti-human interleukin-4 receptor alpha …
Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (T H 2)-mediated allergic diseases such as asthma and atopic dermatitis. Here we isolated anti-human IL-4Rα antagonistic Abs from a large yeast surface-displayed human Ab ...
IL-4Rα signalling in B cells and T cells play differential roles in ...
2023年1月4日 · Dupilumab, an interleukin 4 receptor alpha (IL-4Rα) antagonist was recently approved by FDA as a treatment for AD after it showed positive effects in patients with moderate to severe AD, with...