Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.
Recent advances in understanding the role of IL-4 signaling
Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target ...
Regulation of inflammation by interleukin-4: a review of ...
Keywords: alternative splicing, interelukin-4 receptor, interleukin-4 signaling, alternative macrophage activation. Abstract. Studies of IL-4 have revealed a wealth of information on the diverse roles of this cytokine in homeostatic regulation and disease pathogenesis.
Interleukin - StatPearls - NCBI Bookshelf
2022年8月22日 · Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor and causes IgE and IgG1 isotype selection. It causes Th2 differentiation and proliferation, and it inhibits IFN gamma-mediated activation on macrophages. It promotes mast cell proliferation in vivo. Interleukin-5 (IL-5)
Interleukin 4 - an overview | ScienceDirect Topics
Interleukin-4 is a cytokine that is produced by various cells and plays a role in exerting anti-inflammatory effects during infections like tuberculosis. AI generated definition based on: Tuberculosis , 2009
Tuning the Cytokine Responses: An Update on Interleukin (IL ...
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
IL-4 in the Brain: A Cytokine To Remember | The Journal of ...
2012年11月1日 · CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells.
Evolution and function of interleukin-4 receptor signaling in ...
2020年3月6日 · The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins.
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic ...
Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases.
Regulation of IL4 gene expression by T cells and therapeutic ...
2003年7月1日 · Interleukin-4 (IL-4) is a key cytokine that controls the differentiation of T helper (T H) cells to the T H 2 effector cells that are responsible for cellular immunity and inflammation.