Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132).

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.

2001年1月1日 · Studies to date examining the biology of IL-15 have identified several key nonredundant roles, such as IL-15's importance during natural killer (NK) cell, NK–T cell, and intestinal intraepithelial lymphocyte development and function.

Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair …

Recently, interleukin-15 (IL-15), a member of the four α-helix bundle family of cytokines, has emerged as a candidate immunomodulator for the treatment of cancer. IL-15 acts through its specific receptor, IL-15Rα, which is expressed on antigen-presenting dendritic cells, monocytes and macrophages.

Interleukin 15 (IL-15) is a 14-15 kDa polypeptide that belongs to the 4 alpha-helix-bundle family of cytokines and was originally discovered due to its T cell proliferative activity. It utilizes the signal-transducing beta/gamma polypeptides of the IL-2 receptor complex, thus sharing many biological …

High levels of IL-15 have been observed in rheumatoid arthritis, and IL-15 triggers T-cell growth in sarcoidosis. In addition, IL-15 responsiveness distinguishes malignant B cells from normal B lymphocytes.

Interleukin (IL)-15 is a ubiquitously expressed cytokine existing in both intracellular and secretory forms. Here we review the expression, regulation, and functions of IL15 and its receptors in the brain.

Interleukin-15 (IL-15) is a pleiotropic cytokine, a master regulator that passes a heterogeneous repertoire of activation signals to various cells (Tagaya, Bamford, DeFilippis, & Waldmann, 1996). IL-15 is a 14–15 kDa 4-alpha-helical-bundle type I cytokine.

Recent studies have revealed that interleukin-15 also plays a critical role in cancer immunotherapy. Interleukin-15 agonist molecules have shown that interleukin-15 agonists are effective in inhibiting tumor growth and preventing metastasis, and some are …