Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med. 1995;182(5):1447–1459. doi: 10.1084/jem.182.5.1447.

Interleukin-1 beta (IL1B), a member of the interleukin-1 family, is a potent pro-inflammatory cytokine and plays a crucial role in several inflammatory and autoimmune diseases. IL1B is mainly produced by blood monocytes and tissue macrophages [1,2] .

1. Interleukin-1. Interleukin-1 α and β are prototypic proinflammatory cytokines that exert pleiotrophic effects on a variety of cells and play key roles in acute and chronic inflammatory and autoimmune disorders. There are two IL-1 receptors, IL-1 type 1 receptor (IL-1RI) and IL-1 type 2 receptor (IL-1 RII). IL-1α and IL-1β signal through ...

2019年6月6日 · In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases.

Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory syndromes results in a rapid and sustained reduction in disease severity, ...

Interleukin-1 beta (IL-1β) has emerged as an important therapeutic target, due to its key role in mediating inflammation and tissue damage in different disorders. This study presents a thorough review of the conditions in which (IL-1β) is playing an important role and a summary of the new and ongoing treatments aimed at suppressing its activity.

The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

2025年2月8日 · Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes. Aronica E, et al. J Neuroimmunol, 2005 Mar. PMID 15710472; See all (3205) citations in PubMed

2024年12月25日 · IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer and Diffuse Gastric And Lobular Breast Cancer Syndrome . Among its related pathways are MIF Mediated Glucocorticoid Regulation and …