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Emerging Roles of Impaired Autophagy in Fatty Liver Disease and ...
To tackle conditions involving impaired autophagy and related risks in liver diseases, identification of dysregulated autophagy-related genes/protein markers (SQSTM1/p62, Rab7 and LAMP proteins, autophagosome accumulation, and defective lysosomal function) is important to effectively restore functional autophagic processes .Identification of ...
Autophagy in healthy aging and disease - Nature Aging
2021年8月12日 · Among the many age-related changes previously described, inflammation is linked to autophagy, as impaired autophagy results in inflammation, and has emerged as a major driver of age-related...
Impaired Autophagy: A Mechanism of Mitochondrial Dysfunction …
Autophagy selectively removes abnormal or damaged organelles such as dysfunctional mitochondria. The mitochondrial permeability transition (MPT) is a marker of impaired mitochondrial function that is evident in hepatic ischemia/reperfusion (I/R) ...
Impaired autophagy: The collateral damage of lysosomal storage ...
We have selected five LSDs resulting from defective proteins that govern widely different lysosomal functions including glycogen degradation (Pompe), lysosomal transport (Cystinosis), lysosomal trafficking (Danon), glycolipid degradation (Gaucher) and an unidentified function (Batten) and argue that despite the disparate functions, these protein...
Autophagy in health and disease: A comprehensive review
2018年8月1日 · Autophagy, a conserved catabolic process, plays an immensely significant role in a variety of diseases. However, whether it imparts a protective function in diseases remains debatable. During aging, autophagy gradually subsides, manifested by the reduced formation of autophagic vacuoles and improper fusion of these vacuoles with the lysosomes.
Impaired hepatic autophagy exacerbates hepatotoxin induced
2023年2月21日 · We investigated the role of hepatic autophagy, a cellular survival pathway, in cholestatic liver injury driven by a hepatotoxin. Here we demonstrate that hepatotoxin contained DDC diet impaired...
Autophagy and the cell biology of age-related disease - Nature
2018年11月26日 · Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for cellular homeostasis and adaption to stress. Accumulating evidence indicates that autophagy declines with...
Under these conditions, autophagy is a highly selective process that rids the cells of worn-out organelles (including lysosomes them- selves), toxic protein aggregates, intracellular pathogens, and other
Emerging Roles of Impaired Autophagy in Fatty Liver Disease and ...
Impaired autophagy predominately exists in severe NAFLD, chronic AFLD, and HCC. The reconstitution of normal autophagic functionality could complement current and novel therapeutic regimens for the treatment of these liver diseases .
Impaired autophagy: a link between neurodegenerative and ...
2014年8月19日 · We propose that an impaired autophagy could be involved in neuropsychiatric diseases similarly to NDs, such as AD, PD, ALS and prion diseases. A vicious circle may perpetuate: autophagy is compromised, protein aggregates accumulate and eventually overload cellular degradation and transport systems.
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