Clinical significance of isolated IgE deficiency - UpToDate
2022年10月18日 · Selective immunoglobulin (Ig)E deficiency is defined as a significant decrease in the levels of IgE (<2.5 international units/mL) in a patient whose other immunoglobulin levels, including IgG, IgG subclasses, and IgA levels, are normal.
Low immunoglobulin E flags two distinct types of immune …
2017年1月11日 · Based on this retrospective single‐centre study, the existence of two clinically and immunologically distinct low IgE cohorts can be postulated. The first, defined here as low IgE type 1, is associated with antibody deficiency (low IgG and IgA) and susceptibility to infection and/or autoimmunity.
The other side of the coin: IgE deficiency, a susceptibility factor …
2020年11月20日 · Recent prospective and retrospective studies show that having very low IgE levels, such as those seen in IgE deficiency (IgE<2.5 kU/L), is not without clinical consequences. Patients with ultra-low IgE levels have an elevated risk of cancer of any type.
IgE deficiency: immunodeficiency, atopy & malignancy
2023年10月18日 · Until recently, a very low or absent serum IgE level (IgE < 2.5 kU/L; also known as IgE deficiency) was considered normal. However, recent studies have shown that patients with IgE deficiency have significantly increased rates and risk for cancer.
Low Serum IgE is a Sensitive and Specific Marker for Common …
Although small prior studies have suggested that IgE can be low in common variable immunodeficiency (CVID), the work-up for patients with recurrent infections and suspected hypogammaglobulinemia does not include the routine measurement of serum IgE.
Approach to the Patient With Suspected Immunodeficiency
Immunodeficiency should be suspected when recurrent infections are the following: Severe. Complicated. In multiple locations. Refractory to standard treatment, ie, require multiple courses of oral antibiotics or any need for IV antibiotics to resolve. Caused by unusual organisms. Present in family members.
The Very Low IgE Producer: Allergology, Genetics, …
2023年5月6日 · If IgE antibodies really do participate in immune surveillance mechanisms against tumor cells, then low IgE producers should be at risk of developing malignancies. Indeed, a few reports in the last decade have associated IgE deficiency with malignancies.
Immunoglobulin E deficiency: a forgotten clue pointing to …
2011年6月30日 · We found 6/38 patients investigated had immunoglobulin deficiencies (IgA, IgG and/or IgM), in addition to a low serum IgE. This is a much lower incidence than described in other series 3 but nonetheless represents a significant detection rate (16%).
The biology of IgE - UpToDate
2024年4月12日 · INTRODUCTION. The pathogenesis of many allergic diseases involves "allergic" antibody or immunoglobulin E (IgE) [1]. This topic will review the structure, biology, and functions of IgE. A review of the role of IgE in allergic diseases and more general discussions of immunoglobulin structure and function are found elsewhere.
Low IgE concentration - American Academy of Allergy, Asthma
BACKGROUND: Immunoglobulin E (IgE) deficiency (<2.5 kU/L) has unclear clinical significance. Very little is known about the clinical characteristics of IgE deficiency in patients with Common Variable Immunodeficiency (CVID).