Interleukin-6 receptor - Wikipedia
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
白介素IL-6信号转导及其通路研究概述 - 知乎 - 知乎专栏
IL-6结合受体有两种，一种是特异性受体IL-6R（80kDa I型跨膜蛋白），另一种是gp130，是IL-6家族细胞因子的所有成员的常见受体亚单位。gp130可以在所有细胞表达，但IL-6R的表达受到更多的限制，主要发现于肝细胞、嗜中性粒细胞、单核细胞和CD4+ T细胞。
Interleukin-6 and its receptors: a highly regulated and ... - PubMed
IL-6 induces intracellular signaling pathways after binding to its membrane-bound receptor (IL-6R), which is only expressed on hepatocytes and certain subpopulations of leukocytes (classic signaling). Transduction of the signal is mediated by the membrane-bound β …
IL6R Gene - GeneCards | IL6RA Protein | IL6RA Antibody
2024年10月2日 · This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a ...
Targeting IL-6 trans-signalling: past, present and future prospects
2023年4月17日 · A third mode of IL-6 signalling — known as cluster signalling — involves preformed complexes of membrane-bound IL-6–mIL-6R on one cell activating gp130 subunits on target cells.
Translating IL-6 biology into effective treatments - Nature
2020年4月23日 · Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still’s...
Interleukin-6 signalling as a valuable cornerstone for molecular ...
2021年4月16日 · The biological abilities of interleukin-6 (IL-6) have been under investigation for nearly 40 years. IL-6 works through an interaction with the complex peptide IL-6 receptor (IL-6R). IL-6 is built with four α-chain nanostructures, while two different chains, IL-6Rα (gp80) and gp130/IL6β (gp130), are included in IL-6R.
IL-6 in inflammation, autoimmunity and cancer - PMC
2020年12月18日 · Instead of murine MoAb against IL-6, a humanized MoAb against IL-6 receptor (IL-6R), tocilizumab, has proven successful for treating RA and Castleman’s disease . The IL-6–STAT3 pathway is now considered a major target for the treatment of inflammatory diseases (15, 19, 21, 24–26, 76).
Interplay between interleukin-6 signaling and the vascular ... - Nature
2021年7月12日 · Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms. In this...
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R ...
Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively.