Interleukin 6 - Wikipedia
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
Interleukin 6: at the interface of human health and disease
2023年9月27日 · IL-6 expression is mainly activated by interleukin 1 β (IL-1β) and tumor necrosis factor-alpha (TNFα); however, there are also other ways to promote its synthesis such as Toll-like receptor activation (TLRs), prostaglandins, adipokines, stress response, and other cytokines .
IL6 Gene - GeneCards | IL6 Protein | IL6 Antibody
2024年10月2日 · antibodies-online: Show 259 available IL-6 Proteins ranked by validation data; Compare Top IL-6 Proteins
Interleukin 6 inhibitors: Biology, principles of use, and adverse ...
2024年7月9日 · Interleukin 6 (IL-6) is a potent proinflammatory mediator that is important in immune defense and in immune-mediated disease.
Anti-interleukin-6 - Wikipedia
New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a myokine. IL-6 had previously been classified as a proinflammatory cytokine.
Interleukin-6 and chronic inflammation - Arthritis Research
2006年7月28日 · IL-6 has been shown to be a key player in chronic inflammation, and IL-6 levels are elevated in inflammatory diseases in humans. Expression of IL-6 is enhanced at the site of inflammation, and blockade of IL-6 and IL-6 signalling is effective at prevention and treatment in models of inflammatory diseases (including arthritis and colitis).
Interleukin 6: The biology behind the therapy - Considerations in Medicine
Various biological drugs that target IL-6 are in clinical practice or emerging in clinical trials and pre-clinical development programmes. The challenge is knowing how and when to apply these therapies. In this review, we will explore the biology behind IL-6 directed therapies and identify some key hurdles for future investigation.
Role of Interleukin-6 in Vascular Health and Disease
2021年3月15日 · As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate immune response by leukocytes as well as stromal cells upon pattern recognition receptor activation. IL-6 then recruits immune cells and triggers B …
IL-6 and IL-8: An Overview of Their Roles in Healthy and ... - MDPI
2022年11月23日 · Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones.
The Role of IL-6 in Neurodegenerative Disorders
2024年1月16日 · “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6), a pleiotropic cytokine, significantly affects the activities of nerve cells and plays a pivotal role in neuroinflammation.