Targeting IFN/STAT1 Pathway as a Promising Strategy to …
This review focuses on the oncogenic function of the IFN/STAT1 pathway, emphasizing the major signaling pathway in radiation sensitization. Furthermore, it highlights the possibility of mediatory roles of the IFN/STAT1 pathway as a prognostic therapeutic target in the modulation of resistance to radiotherapy and chemotherapy.
30岁了！ CELL重磅综述：JAK-STAT通路全面解读！ - 健康界
2022年11月14日 · 直接或间接靶向stat的病毒抗免疫策略突出了stat介导的ifn信号通路作为抗病毒防御的重要性。stat导向的ifn拮抗机制包括靶向stat降解、隔离和细胞质滞留。黄病毒，包括登革热病毒和寨卡病毒，以stat2为目标进行蛋白酶体依赖性降解。
干扰素信号途径 - 知乎 - 知乎专栏
干扰素名字源于英文interferon（IFN），所有的干扰素信号都会通过JAK-STAT信号通路，这是由受体经Janus家族激酶（JAK和TYK）和STAT，最终诱导干扰素刺激基因ISG的转录激活。
Cross-regulation of Signaling and Immune Responses by IFN-γ and STAT1
The major STAT protein activated by IFN-γ is STAT1. Many IFN-γ functions are mediated by direct activation of immune effector genes by STAT1, including genes encoding anti-viral proteins, microbicidal molecules, phagocytic receptors, chemokines, cytokines, and …
Mechanisms of type-I- and type-II-interferon-mediated signalling …
2005年5月1日 · The transcription of type II IFN (IFN-γ)-dependent genes is regulated by GAS elements, and STAT1 is the most important IFN-γ-activated transcription factor for the regulation of these ...
IFNγ: signalling, epigenetics and roles in immunity ... - Nature
2018年6月19日 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated...
Amplification of IFN-α-induced STAT1 activation and ... - Nature
2004年10月3日 · Increased STAT1 expression contributed to enhanced IFN-α-induced STAT1 activation in primed macrophages. These results identify a mechanism by which crosstalk between cytokine and immune...
Stat1-dependent and -independent pathways in IFN-γ …
We summarize recent advances in the understanding of IFN-γ-mediated signal transduction and the use of microarrays for the study of IFN-γ-dependent regulation of gene expression. The results reveal that both Stat1-dependent and -independent pathways play important roles in the full range of biological responses to IFN-γ.
The Interaction of the IFN γ /JAK/STAT1 and JAK/STAT3 Signalling ...
With inhibition of inhibiting the JAK/STAT3 signalling pathway by STAT3 inhibitors, we found IFNγ-JAK-STAT1 pathway activation by IFNγ could further keep lung adenocarcinoma cells from proliferation and promote its apoptosis. The inhibition of the JAK/STAT3 pathway results in the upregulation of JAK1/2, STAT1, IRF1, IRF9, and PD-L1 and ...
Modulation of the activation of Stat1 by the interferon-gamma …
We report that the rate of activation of Stat1 can be altered in HeLa cells by overexpressing either the IFN-gammaR1 chain or the IFN-gammaR2 chain. These alterations occur in hematopoietic cell lines: Raji cells and monocytic cell lines, which have average and above-average IFN-gammaR2 surface expression, activate Stat1 similarly to HeLa cells ...