Hypoxic pulmonary vasoconstriction (HPV), also known as the Euler–Liljestrand mechanism, is a physiological phenomenon in which small pulmonary arteries constrict in the presence of alveolar hypoxia (low oxygen levels).

2017年2月22日 · Hypoxic pulmonary vasoconstriction (HPV) is a reflex contraction of vascular smooth muscle in the pulmonary circulation in response to a low regional partial pressure of oxygen. It is an important mechanism for matching of …

2001年3月6日 · Hypoxic vasoconstriction mainly occurs in small pre-capillary arterioles [3,4,5] but small pulmonary veins also constrict in response to hypoxia, although not to more than 20% of the total change in PVR .

2017年1月24日 · Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes …

2018年1月8日 · Hypoxic pulmonary vasoconstriction (HPV) is an intrinsic property of the lung where vascular smooth muscle will constrict pulmonary circulation in response to areas of hypoxia. In other words, if an alveolus is not being well …

2023年2月9日 · Hypoxic pulmonary vasoconstriction (HPV) plays an important role in patients presenting with heterogeneous respiratory diseases such as atelectasis, chronic obstructive pulmonary disease (COPD), pneumonia, and acute respiratory distress syndrome (ARDS).

Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxy-genation. Alterations in PO2 are sensed by a vascular redox O2 sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria.

Hypoxic pulmonary vasoconstriction (HPV) is a reflex contrac-tion of vascular smooth muscle in the pulmonary circulation in response to a low regional partial pressure of oxygen. It is an important mechanism for matching of regional perfusion and ventilation in the lung.

Hypoxic pulmonary vasoconstriction (HPV) rapidly and reversibly matches lung ventilation (V) and perfusion (Q), optimizing oxygen uptake and systemic oxygen delivery.

In this brief review, we highlight selected recent findings and ongoing controversies which continue to animate the study of this remarkable and unique response of the pulmonary vasculature to hypoxia.