2021年4月20日 · Schematic illustration of the feedback system regulating the hypothalamic-pituitary-thyroid axis. Thyroid hormones exert negative feedback effect at the level of hypothalamic TRH neurons and of pituitary gland. The central feedback effect of thyroid hormones depends on the circulating T4 levels.

The hypothalamic–pituitary–thyroid axis (HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress.

2021年4月5日 · The hypothalamus-pituitary-thyroid axis is one of several hormone regulatory systems from the hypothalamus to the pituitary and ultimately to the peripheral target organs. The hypothalamus and the pituitary gland are in close anatomical proximity at the base of the brain and extended through the pit …

2021年4月5日 · The hypothalamus-pituitary-thyroid axis responds to fasting by afferent input from neurons originating outside the paraventricular nucleus and can influence the secretion of the hypophysiotropic TRH-secreting neurons.

The hypothalamic–pituitary–thyroid axis (HPT axis) is under the control of neurons located in the medial region of the PVN that synthesize and release thyrotropin-releasing hormone (TRH) into the pituitary portal circulation.

2023年6月5日 · The thyroid gland, anterior pituitary gland, and hypothalamus comprise a self-regulatory circuit called the hypothalamic-pituitary-thyroid axis. The main hormones produced by the thyroid gland are thyroxine or tetraiodothyronine (T4) and triiodothyronine (T3).

2016年6月13日 · The hypothalamus-pituitary-thyroid (HPT) axis determines the set point of thyroid hormone (TH) production. Hypothalamic thyrotropin-releasing hormone (TRH) stimulates the synthesis and secretion of pituitary thyrotropin (thyroid-stimulating hormone, TSH), which acts at the thyroid to stimulate all s …

The hypothalamic-pituitary thyroid (HPT) axis was the first neuroendocrine axis to be identified, a major discovery which introduced the era of neuroendocrinology and transformed the diagnostic and therapeutic approach in patients with thyroid disease.