Topical recombinant human Nerve growth factor (rh-NGF) is ...
2020年2月25日 · Topical application of rh-NGF twice daily for 3 weeks significantly improves RGC survival as shown by reduced RGC apoptosis in vivo and increased RGC population in the …
A Vicious NGF-p75NTR Positive Feedback Loop Exacerbates the …
2023年11月12日 · We used a human retinal pigment cell line, ARPE-19 cells, to investigate the effects of hNGF and its analogs, mouse NGF (mNGF) and painless NGF (pNGF), on cell …
A Vicious NGF-p75NTR Positive Feedback Loop Exacerbates the
2023年11月12日 · We used a human retinal pigment cell line, ARPE-19 cells, to investigate the effects of hNGF and its analogs, mouse NGF (mNGF) and painless NGF (pNGF), on cell …
Nerve growth factor: from the early discoveries to the potential ...
It has been reported that NGF induces modification of pre-synaptic elements in adult visual system [165,166], prevents the shift in ocular dominance distribution of visual cortical neurons …
重组人神经生长因子：眼科的下一个必争赛道 - 知乎
2023年12月14日 · rhNGF以其独特的优势，在多个适应症上开展了临床试验，并在 眼科罕见病 领域取得了一定的成绩，国内也已开展了包括 视神经损伤 、神经营养性角膜炎、干眼症等在内 …
(PDF) A Vicious NGF-p75NTR Positive Feedback Loop
2023年11月12日 · We used a human retinal pigment cell line, ARPE-19 cells, to investigate the effects of hNGF and its analogs, mouse NGF (mNGF) and painless NGF (pNGF), on cell …
A p75 neurotrophin receptor‐sparing nerve growth factor protects ...
2024年9月9日 · Retinal ganglion cells (RGCs) are the output stage of retinal information processing, via their axons forming the optic nerve (ON). ON damage leads to axonal …
Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a …
2023年2月22日 · It has been reported that rhNGF significantly inhibits retinal ganglion cell (RGC) apoptosis and increases the RGC number in optic neuropathy model rats, confirming that …
A p75 neurotrophin receptor-sparing nerve growth factor
Our data point to microglia as a new cell target through which NGF-induced TrkA signalling exerts neuroprotection of the RGC, emphasizing hNGFp as a powerful treatment to tackle retinal …
Challenges and progress of neurodrug: bioactivities, production …
2023年12月4日 · Nerve growth factor (NGF) is a vital cytokine that plays a crucial role in the development and regeneration of the nervous system. It has been extensively studied for its …