Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the HBB gene, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). [5] .

Dec 25, 2024 · HBB (Hemoglobin Subunit Beta) is a Protein Coding gene. Diseases associated with HBB include Sickle Cell Disease and Beta-Thalassemia, Dominant Inclusion Body Type. Among its related pathways are Innate Immune System and Erythrocytes take up carbon dioxide and release oxygen.

α (HBA) 和β (HBB) 位点决定了成人血红蛋白 Hb A 中两种多肽链的结构。 正常的成人血红蛋白四聚体由两条 α 链和两条 β 链组成。 突变的 β 珠蛋白会导致镰状细胞性贫血。 缺乏β链会导致β-零地中海贫血。 可检测到的 β 珠蛋白数量减少会导致 β 加地中海贫血。 β-珠蛋白簇中基因的顺序是 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'。 [RefSeq 提供，2008 年 7 月]

Feb 9, 2025 · The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.

Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells. In adults, hemoglobin typically consists of four protein subunits: two subunits of beta-globin and two subunits of a protein called alpha-globin, which is produced from another gene called HBA .

血红蛋白亚基β （Beta Globin， β-珠蛋白， 血红蛋白β， 血红蛋白β）是 Globin 蛋白质，由 HBB 基因，与alpha globin一起（HBA），构成最常见的形式 血红蛋白 在成年人中， 血红蛋白a （HBA）。 [5] 它长147个氨基酸，分子量为15,867 da。 正常成人人类HBA是一个 异驱动器 由两个α炼和两个β链组成。 HBB由 HBB 基因开 人类染色体11。 基因中的突变产生几种蛋白质的变异，与遗传疾病（例如 镰状细胞性贫血症 和 βthalassya，以及有益的特征，例如 对疟疾的遗传 …

The results show that in the alpha subunit the low to high affinity transition is achieved by a proximal effect that mostly affects oxygen dissociation and is the driving force of the allosteric transition, while in the beta subunit the affinity change results from a complex interplay of proximal and distal effects, including an increase in the ...

Jan 4, 2025 · Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. HbA2 levels in normal adults are influenced by two distinct genetic mechanisms. Imputation-based meta-analysis of severe malaria in three African populations.

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein (s) are secreted or actually retained in intracellular locations or membrane-attached.

Hemoglobin Rush (beta 101 (g3) glutamine): a new unstable hemoglobin causing mild hemolytic anemia. A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta 67 [E11] Val-Met->Asp). ...