2021年5月24日 · Remarkable amyloid deposition in the gastric mucosa through the subserosa might have caused gastric perforation. Co‐deposition of IgM with amyloid A protein in the renal glomerulus was the finding of note. Active production of SAA in stimulated hepatocytes and acinar cells of the pancreas and salivary gland is also discussed.

Gastrointestinal amyloidosis (GIA), a protein deposition disorder, represents a complex common pathway that encompasses multiple etiologies and presentations. It represents a significant diagnostic and treatment challenge. The disease results from ...

Localized gastric amyloidosis (LGA) is a rare disease characterized by abnormal extracellular deposition of amyloid protein restricted to the stomach and it is confirmed by positive results of Congo red staining. Over decades, only a few cases have been reported and studies or research focusing on it are few.

In this review of the literature, we describe the subtypes of amyloidosis, with a primary focus on the epidemiology, pathogenesis, clinical features, diagnosis and treatment strategies available for GI amyloidosis. Keywords: Gastroenterology, …

3 天之前 · Amyloidosis is a heterogeneous group of disorders characterized by the extracellular deposition of amyloid fibrils, which disrupt normal organ function [].These fibrils are composed of protein fragments that adopt a distinctive β-pleated sheet conformation, and when stained with Congo Red dye, they display green birefringence under cross-polarized light, a hallmark of amyloid deposits [].

2021年7月29日 · Gastrointestinal (GI) bleeding due to amyloid deposition is infrequent. Previous literature describes upper GI bleeding (UGIB) in patients with known amyloid disease. Here, we describe a case of recurrent UGIB that ultimately led to a diagnosis of GI amyloidosis and multiple myeloma in a patient with no history of either.

Generalized (systemic) amyloid deposition can be seen in many tissues, including gastrointestinal tract, spleen, liver, kidney, tongue, and mesenteric lymph node. Amyloid deposition in the glandular stomach (Figure 1 and Figure 2) generally occurs in the lamina propria and submucosa.

Amyloid deposition in the stomach can cause diffuse inflammation manifesting as a GI bleed, as in the case of our patient. Diagnosis requires biopsy with Congo red staining. Management and prognosis depend on the type and extent of deposition.

The type, location, and extent of fibril deposition generates variable clinical manifestations. Gastrointestinal (GI) amyloid is infrequent and its presentation may be suggestive of more prevalent etiologies. We aim to describe and discuss a case of acute upper GI bleeding secondary to gastrointestinal amyloid. CASE DESCRIPTION/METHODS:

2024年9月11日 · Amyloidosis is a generic term that refers to the extracellular tissue deposition of fibrils composed of low molecular weight subunits (5 to 25 kD) of a variety of serum proteins, many of which circulate as constituents of plasma [1].