Jan 7, 2022 · In this study, we explore our ability to influence aneurysm growth in a topical elastase plus β-Aminopropionitrile (BAPN) mouse model by varying elastase concentration and by altering the...

Sep 26, 2024 · Conclusion: The C57BL/6N mouse substrain is suitable for establishing a model of AAA via elastase infusion. Abdominal aortic aneurysm (AAA) is a major aortic disease characterized by local expansion of the abdominal aorta (1 – 3).

Feb 3, 2023 · Coats and Auld in 1893 discovered early aneurysms developed by the blood passing through atheromatous ulcers, and elastic fibers were found to break suddenly or disappear gradually by the...

Feb 5, 2024 · Neutrophil elastase inhibition by sivelestat (ONO-5046) attenuates AngII-induced abdominal aortic aneurysms in apolipoprotein E-deficient mice.

Dec 1, 2009 · We introduce a new, simple technique to create reliable AAAs that simulate human aneurysms. Experimental models of AAAs were created in 71 rats by means of a 20-minute application of intraluminal elastase (30 U) and extraluminal calcium chloride (0.5M) in the 1-cm segment of infrarenal abdominal aorta (group EC, n = 26).

Currently, there are several distinct experimental models of AAA, each emphasizing a different aspect in the pathogenesis of AAA. The elastase-induced AAA model is the second most used rodent AAA model. This model involves direct infusion or application of porcine pancreatic elastase (PPE) to the infrarenal segment of the aorta.

Nov 5, 2021 · We tested the hypothesis that the reversal of abdominal aortic aneurysm by pentagalloyl glucose-loaded nanoparticles (PGG-NPs) therapy that targets degraded elastin suppresses inflammatory and immune markers to ameliorate the pathophysiology of the disease in advance stage aneurysm in a porcine pancreatic elastase (PPE)-induced mouse model of AAA.

Feb 11, 2022 · The elastase-induced AAA model is the second most used rodent AAA model. This model involves direct infusion or application of porcine pancreatic elastase (PPE) to the infrarenal segment of the aorta.

Feb 6, 2023 · Histopathological examination revealed aortic wall thickening, degradation of elastin fibers, loss of smooth muscle cells, more vasa vasorum, enhanced extracellular matrix degradation, augmented collagen synthesis, upregulated apoptosis and proliferation capacity of smooth muscle cells, and increased macrophages and CD4 + T cells infiltration in...

Jul 1, 2018 · The elastase induced murine aneurysm model is considered the most advanced disease mimicking model for experimental in vivo abdominal aortic aneurysm research. In this detailed microsurgical study, the classical model is evolved through modifications based on surgical practice with alterations to the aortic outflow and by enabling elastase ...