Ubiquitination regulates ER-phagy and remodelling of ... - Nature
2023年5月24日 · Our results show that ubiquitination enhances RHD functions via receptor clustering, facilitates ER-phagy and controls ER remodelling in response to cellular demands.
Foundations of ER-phagy regulation - Nature
2020年3月17日 · ER-phagy is a selective type of autophagy, whereby parts of the endoplasmic reticulum (ER) network (sheets or tubules) are engulfed by autophagosomes through specific ER-phagy receptors and...
ER-Phagy: A New Regulator of ER Homeostasis - PMC
2021年7月9日 · ER-phagy is a selective form of autophagy that ensures the timely removal of damaged ER, thereby protecting cells from damage caused by excessive ER stress. As ER-phagy is a newly identified form of autophagy, many receptor-mediated ER-phagy pathways have been discovered in recent years.
ER-phagy: mechanisms, regulation, and diseases connected to the ...
2022年2月22日 · ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum (ER) within lysosomes or vacuoles. It is part of the self-digestion (i.e., autophagic) programs recycling cytoplasmic material and organelles, which rapidly mobilize metabolites in cells confronted with nutrien ….
ER-Phagy: A New Regulator of ER Homeostasis - PubMed
2021年7月9日 · ER-phagy is a selective form of autophagy that ensures the timely removal of damaged ER, thereby protecting cells from damage caused by excessive ER stress. As ER-phagy is a newly identified form of autophagy, many receptor-mediated ER-phagy pathways have been discovered in recent years.
ER-phagy and human diseases | Cell Death & Differentiation
2019年10月28日 · Only recently, several receptors that mediate the specific degradation of endoplasmic reticulum (ER) components via autophagy have been identified (the process known as ER-phagy or...
ER-phagy: mechanisms, regulation, and diseases connected to the ...
ER-phagy is a group of fundamental biological processes that, through distinct mechanisms, lead to lysosomal turnover of selected subdomains of the endoplasmic reticulum (ER).
ER-phagy, ER homeostasis, and ER quality control: Implications …
The lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, called ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of ER-phagy.
ER-Phagy: Quality and Quantity Control of the Endoplasmic
2023年1月3日 · ER-phagy is defined as the degradation of part of the ER by the vacuole or lysosomes, and there are at least two types of ER-phagy: macro-ER-phagy and micro-ER-phagy. In macro-ER-phagy, ER fragments are enclosed by autophagosomes, which is mediated by ER-phagy receptors.
ER-phagy requires Lnp1, a protein that stabilizes ... - PubMed
2018年7月3日 · The endoplasmic reticulum (ER) forms a contiguous network of tubules and sheets that is predominantly associated with the cell cortex in yeast. Upon treatment with rapamycin, the ER undergoes degradation by selective autophagy.