Dubuque (/ d ə ˈ b juː k / ⓘ, dəb-YOOK) is a city in and the county seat of Dubuque County, Iowa, United States, located along the Mississippi River. [3] At the time of the 2020 census, the population of Dubuque was 59,667. [4] The city lies at the junction of Iowa, Illinois, and Wisconsin, a region locally known as the Tri-State Area. It ...