Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by an extensive skin rash in association with visceral organ involvement, lymphadenopathy, eosinophilia, and atypical lymphocytosis.

The first order of action with DRESS is to identify and stop the offending medication. Treatments of DRESS Syndrome will vary by case, taking into consideration severity, other existing medical conditions and the presence of viral reactivation. The most commonly accepted core treatment for DRESS is systemic corticosteroids and oral prednisone.

Drug hypersensitivity syndrome is sometimes also called drug reaction with eosinophilia and systemic symptoms (DRESS), and drug-induced hypersensitivity syndrome (DIHS). The syndrome is classified as a severe cutaneous adverse reaction (SCAR) .

DRESS is a severe form of adverse drug reaction with potential for significant morbidity and mortality. Recent research advances may improve clinical care. HLA screening can now be performed to prevent disease in susceptible patients and …

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a distinct, severe, idiosyncratic reaction to a drug characterized by a prolonged latency period. It is followed by a variety of clinical manifestations, usually fever, rash, lymphadenopathy, eosinophilia, and a wide range of mild-to-severe systemic presentations.

Diagnosis. Patients with DRESS can have a broad range of symptoms, which can include fever, rash, facial swelling, enlarged lymph nodes and kidney or liver injury. Most patients with DRESS will have an abnormal level of blood cells found in their blood tests, which are called eosinophils.

DRESS usually involves one or more organ and hematologic (blood) abnormalities. Because this syndrome exists on a continuum, some, but not all, of these symptoms may appear through the course of illness. Symptoms may continue to deteriorate and flare-ups may occur for weeks and even months after stopping the offending medication. Organs

Mar 1, 2023 · The diagnosis of DRESS is sometimes made late and can be challenging, due to its variety of clinical presentations. The original diagnostic criteria were proposed by Bocquet et al 1 and included a rash due to drugs, hematological alterations (eosinophils greater than 1500 × 10 9 /L and the presence of atypical lymphocytes) and systemic ...

DRESS Syndrome — also called DIHS (Drug-Induced Hypersensitivity Syndrome) — is a delayed, life-threatening hypersensitivity drug reaction that can cause severe organ dysfunction. This condition may involve viral reactivation and result in long-term complications. DRESS occurs from taking one of over 50 medications.

The diagnosis of DRESS syndrome is complex and often requires evaluation from a physician before ruling out other causes. DRESS syndrome should be suspected if a diffuse rash erupts and is accompanied by fever, facial edema, and enlarged lymph two to six weeks after starting a new high-risk medication.