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    https://en.wikipedia.org › wiki › Dithiothreitol

    Dithiothreitol - Wikipedia

    • Dithiothreitol (DTT) is an organosulfur compound with the formula (CH(OH)CH2SH)2. A colorless compound, it is classified as a dithiol and a diol. DTT is redox reagent also known as Cleland's reagent, after W. Wallace Cleland. The reagent is commonly used in its racemic form. Its name derives from the four-carbon sugar, threose. DTT has an epimeric ('sist… 展开

    Synthesis

    The traditional route to dithiothreitol (and its isomer dithioerythritol) is sulfidation of the extremely lachrymatory 1,4-Dibromobut-2-ene [zh]. Modern industrial syntheses instead use related epoxides and hydrogen sulfide. … 展开

    Reducing agent

    DTT is a reducing agent; once oxidized, it forms a stable six-membered ring with an internal disulfide bond. It has a redox potential of −0.33 V at pH 7. The reduction of a typical disulfide bond proceeds by two sequential … 展开

    Applications

    DTT is used as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen. Dimerization greatly lowers the efficie… 展开

    What is dithiothreitol (DTT)?
    Dithiothreitol (DTT) is an organosulfur compound with the formula (CH (OH)CH2SH)2. A colorless compound, it is classified as a dithiol and a diol. DTT is redox reagent also known as Cleland's reagent, after W. Wallace Cleland. The reagent is commonly used in its racemic form. Its name derives from the four-carbon sugar, threose.
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