Hematopoiesis and its disorders: a systems biology approach
2010年3月25日 · We will introduce key concepts, terms, and models of systems biology (for a glossary, see Appendix at the end of the article) and discuss how systems biology is enhancing our understanding of the pathophysiology and treatment of blood disorders.
Hematopoiesis: Definition, Types & Process - Cleveland Clinic
2022年10月12日 · Hematopoiesis ensures you have a healthy supply of blood cells to supply oxygen to your tissue (red blood cells), fight infection (white blood cells) and clot your blood when you’re injured (platelets). Most blood cells get made in your bone marrow.
The genetics of human hematopoiesis and its disruption in disease
2019年7月17日 · Nearly all clinically measured hematopoietic traits exhibit extensive variation and are highly heritable, underscoring the importance of genetic variation in these processes. This review explores how human genetics have illuminated our understanding of hematopoiesis in health and disease.
Histology, Hematopoiesis - StatPearls - NCBI Bookshelf
2023年5月1日 · Structure. The primary locations of hematopoiesis change throughout life. At the beginning of the fetal period, it begins in the yolk sac and aorta-gonad-mesonephros, eventually transitioning into liver, spleen, and finally the bone marrow and lymph nodes.
Understanding the Hematopoiesis Process - Verywell Health
2023年7月12日 · Hematopoietic malignancies include leukemia, lymphoma, and myeloma. Hematopoietic neoplasm covers a wide range of blood disorders, some of which are chronic conditions that you live with, and others are more apt to progress with serious complications and decreased survival.
Disorders of the Hematopoietic System | SpringerLink
This chapter focuses on the relationship between exposure to environmental chemicals and physical agents and disorders of the hematopoietic system. The hematopoietic system includes the formed elements of the blood as well as the bone marrow, spleen, lymph nodes, and reticuloendothelial tissue.
Hematologic Disorders - SpringerLink
2021年8月31日 · Disorders of the hematopoietic system can arise from impaired production of blood cells, overproduction of blood cells, destruction of existing blood cells, or abnormal function of blood cells or blood cell constituents.
Introduction to Blood and Hematopoietic Tissues
The identity and function of the major hematopoietic and lymphoid tissues: the bone marrow, spleen, thymus, and lymph nodes. Regardless of what kind of doctor a student decides to become, a well-grounded understanding of disorders of the blood and the hematopoietic tissues is …
Hematopoiesis: Definition, embryology and cell lines | Kenhub
2023年11月9日 · Haematological disorders. Haematological disorders can be discussed based on there is a decrease, increase or abnormal function of individual or multiple mature cells or entire cell lines. These abnormalities may be dependent on one of the following:
Disorders of Hemoglobin Structure: Sickle Cell Anemia and …
Hemoglobinopathies are the most common inherited red cell disorders worldwide. Among these disorders, sickle cell disease (SCD) and thalassemias constitute a major public health problem. SCD is caused by a glutamic acid to valine substitution at the …