Intestinal epithelium - Wikipedia
The intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelium its main functions are absorption, and secretion.
Colonic epithelial cell diversity in health and inflammatory bowel ...
2019年2月27日 · We have characterized an absorptive cell type, the BEST4/OTOP2 cells, which are capable of pH sensing and may maintain luminal homeostasis through regulation of the GC-C signalling pathway.
Cells of the human intestinal tract mapped across space and time
2021年9月8日 · Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and...
Colon: Anatomy, histology, composition, function | Kenhub
2023年10月30日 · The colon may be subdivided into four parts: ascending, transverse, descending and sigmoid colon. The ascending colon lies secondary retroperitoneally on the right side of the abdominal cavity and moves towards the …
Cells of the human intestinal tract mapped across space and time
2021年9月8日 · Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages. Go to: Main.
Intestinal epithelial cells: regulators of barrier function and …
2014年2月25日 · Metrics. Key Points. Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. Secretory...
Development and differentiation of the intestinal epithelium
2002年10月18日 · Such critical pathways as the hedgehog, bone morphogenetic protein, Notch, Sox, and Wnt systems are used both in embryologic and adult times of gut development. We focus on and review the roles of these factors in gut epithelial cell development and differentiation.
The Intestinal Epithelium: Central Coordinator of Mucosal …
2018年4月28日 · In general, the majority of cell types located in the colon are also found in the small intestine; these include the enterocytes (also referred to as colonocytes in colon), enteroendocrine cells, goblet cells, and tuft cells.
Intestinal Epithelium - an overview | ScienceDirect Topics
It is composed of three main differentiated cell types: columnar, mucous, and enteroendocrine cells. The most prevalent cells are the columnar cells (also known as absorptive cells or enterocytes) and they are involved in most intestinal functions.
Bioengineered human colon organoids with - Cell Press
2024年8月1日 · Cells clustered into 8 subpopulations and annotation with canonical markers revealed that human mini-colons harbored most of the cell types of the native colon, including a population of transit-amplifying (TA) cells; stem cells; colonocytes, including early, mature, crypt-top, and absorptive BEST4 + colonocytes; and goblet and enteroendocrine ...