CLDN1 - Wikipedia
The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal …
CLDN1 Gene - GeneCards | CLD1 Protein | CLD1 Antibody
2024年10月1日 · CLDN1 (Claudin 1) is a Protein Coding gene. Diseases associated with CLDN1 include Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis and Sclerosing …
Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment
In the present review, CLDN1‑, 4‑, 6‑ and 18.2‑targeting investigational drugs in clinical trials are discussed. CLDN18.2‑directed therapy for patients with gastric and other types of cancer is …
Claudin-1, A Double-Edged Sword in Cancer - PubMed
2020年1月15日 · Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, lower …
Claudins and the Modulation of Tight Junction Permeability
Claudin-1 is expressed in the epidermis and clearly plays an important role in the skin barrier (38, 97). Knockout of claudin-1 in mice leads to loss of the tight junctional barrier to water and …
CLDN1 claudin 1 [Homo sapiens (human)] - Gene - NCBI
2024年11月2日 · Title: Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation. Immunohistochemical Expression of Claudin-1 …
Claudin-1-targeted therapies break barriers in precision oncology
Targeting claudin-1 offers a promising approach for treating solid tumours by selectively killing cancer cells and breaking down barriers to immunotherapy.
9076 - Gene ResultCLDN1 claudin 1 [ (human)] - National Center …
claudin-1, senescence-associated epithelial membrane protein 1. CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders. Claudin-1 as a novel target gene induced in …
Claudin 1 - an overview | ScienceDirect Topics
Claudin-1, an important member of the claudin family in the tight junction protein (TJ), shows its action in various tissues, especially in liver (Douam et al., 2014). Claudin-1 also participates in …
Claudin-1 decrease impacts epidermal barrier function in …
2020年2月6日 · Claudin-1 decrease induced keratinocyte-autonomous IL-1β expression and fostered inflammatory epidermal responses to non-pathogenic Staphylococci.