Chemogenetics is the process by which macromolecules can be engineered to interact with previously unrecognized small molecules. Chemogenetics as a term was originally coined to …

Chemogenetics refers to the engineering of protein receptors to respond to previously unrecognized small molecules. Chemogenetic tools are actuators for specific cellular …

Chemogenetics refers to the modulation of neural activity through neurotransmitter receptors that are genetically engineered to bind specific exogenous ligands, usually biologically inert small …

Chemogenetics generalizes chemical control of cellular pathways by engineering a limited set of tunable, modular, and selective receptor/ligand systems that can be applied to virtually any cell …

Chemogenetics permits targeted, noninvasive, and reversible perturbations of cellular function. Here, we developed a set of modular ion channels and selective, exceptionally potent agonists …

2023年12月14日 · Chemogenetics is a technique for modulating engineered proteins using small molecules. In this Primer, Kang et al. describe the key aspects of designing receptors and …

Chemogenetics involves dissecting cellular signaling mechanisms via the viral delivery of engineered ligand-sensitive molecules to specific cells.

Like optogenetics, chemogenetics can be used for selective interrogation of neuronal circuitry and manipulation of behavioural output. Two different strategies have been developed that allow …

2020年6月11日 · The four main factors in which chemogenetics and optogenetics differ are: Timing; Targeted manipulation; Controlling stimulation; Invasiveness ; Choosing the best set of …

2017年8月4日 · Designer receptors exclusively activated by designer drugs (DREADDs) constitute a powerful chemogenetic strategy that can modulate nerve cell activity in freely …