2018年4月6日 · Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective — a concept that is now well accepted...

2013年11月26日 · This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic systems that contributes to degradation of intracellular proteins in lysosomes.

2022年12月1日 · A fraction of the cellular proteome can be selectively targeted to lysosomes for degradation within this organelle by a process known as chaperone-mediated autophagy (CMA). A dedicated network of genes and their protein products contribute to …

Chaperone-mediated autophagy (CMA) is a lysosomal pathway of proteolysis that is responsible for the degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation. Molecular chaperones in the cytosol and in the lysosomal lumen stimulate this …

2012年6月28日 · In this review we focus on a type of selective autophagy, known as chaperone-mediated autophagy (CMA), so far only identified in mammalian cells, that was set apart from other types of autophagy due to the unique way in which its substrates, mainly cytosolic proteins, enter the lysosome [5].

Chaperone-mediated autophagy (CMA) is a selective lysosomal pathway for the degradation of cytosolic proteins. We review in this work some of the recent findings on this pathway regarding the molecular mechanisms that contribute to substrate ...

2023年8月30日 · Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway that eliminates substrate proteins through heat-shock cognate protein 70 recognition and lysosome-associated membrane protein type 2A-assisted translocation. It is distinct from macroautophagy and microautophagy.

2011年2月15日 · Chaperone-mediated autophagy (CMA) is an intracellular catabolic pathway that mediates the degradation of a selective subset of cytosolic proteins in lysosomes (Dice, 2007; Cuervo, 2010; Kon and Cuervo, 2010; Orenstein and Cuervo, 2010).

This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen.

Chaperone-mediated autophagy (CMA) is a type of autophagy in which a chaperone-dependent selective mechanism delivers and degrades cellular components. It is a lysosome-based catabolic process that occurs to maintain cellular homeostasis by catabolic lysis of excess or superfluous soluble cytosolic proteins.