Metastatic cervical cancer: Diagnosis, treatment, and outlook
2023年4月28日 · Metastatic cervical cancer has spread to regions beyond the cervix, such as the lymph nodes, lungs, or liver. Read about diagnosis, treatment, and outlook here.
Patterns of metastases in cervical cancer: a population-based study
In this paper, we analyzed 1347 metastatic cervical cancer patients from surveillance epidemiology and end results (SEER) database for the following aims: (1) to investigate the incidence of different metastatic sites in cervical cancer; (2) to explore the relationship among site-specific patterns of metastasis and overall survival of ...
Management of recurrent or metastatic cervical cancer
In the majority of cases, metastatic cervical cancer is not curable. However, for some patients who present with recurrent disease in the pelvis (locoregional recurrence) or with limited distant metastatic disease, surgical treatment is potentially curative.
Within the skeletal system, the vertebral column is the most common site of metastases, and 8% to 15% of vertebral metastases are in the cervical spine, consisting, anatomically and biomechanically, of the occipitocervical junction, subaxial spine, and cervicothoracic junction.
Advances in diagnosis and treatment of metastatic cervical cancer
For cervical cancer patients, there are two types of metastasis: hematogenous metastasis and lymphatic metastasis. Patients with hematogenous metastasis have a higher risk of death than those with lymphatic metastasis.
Recurrent or primary metastatic cervical cancer: current and …
In this review, we discuss historical, current, and emerging treatment options for patients with primary metastatic or recurrent CC. Historically, disseminated recurrent CC was treated with cisplatin monotherapy that was considered as the standard of care (SOC) since the results of the phase II Gynecologic Oncology Group (GOG)-26 trial.
Cervical Cancer Metastasis - ScienceDirect
2017年1月1日 · In this chapter, our aim is to provide a broad overview of risk factors, modes of metastasis and major molecular factors and signaling pathways involved in the progression and metastasis of CxC.
Cervical Cancer Metastasis - ScienceDirect
2017年1月1日 · Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver.
Patterns of metastases in cervical cancer: a population-based …
2020年7月1日 · To investigate the incidence, prognosis, and treatment modality of different metastatic sites in cervical cancer. Methods: We used the surveillance epidemiology and end results (SEER) database to collect cervical cancer patients with metastasis from 2010-2016.
If cervical cancer spreads - Canadian Cancer Society
Cancer cells can spread from the cervix to other parts of the body. This spread is called metastasis. Understanding how a type of cancer usually grows and spreads helps your healthcare team plan your treatment and future care.
The type of metastasis is a prognostic factor in disseminated cervical …
2010年9月28日 · In patients with disseminated cervical cancer, the type of metastasis and treatment completion are potential prognostic factors for prolonged survival. VDRCC might be overtreatment for those with hematogenous metastases, but a promising approach for those who have only lymphatic metastases.
Current Management of Locally Advanced and Metastatic Cervical Cancer ...
2022年3月14日 · Just more than half of invasive cervical cancer cases involve regional or distant metastases at diagnosis. 7 Although early disease is often asymptomatic and discovered through routine screening, patients with locally advanced cervical cancer are more likely to present with symptoms such as irregular vaginal bleeding, postcoital bleeding, and va...
Advances in diagnosis and treatment of metastatic cervical cancer
We reviewed the relevant literature concerning the treatment and diagnosis of metastatic cervical cancer. There are two types of metastasis related to different treatments and survival rates: hematogenous metastasis and lymphatic metastasis. Patients with hematogenous metastasis have a higher risk of death than those with lymphatic metastasis.
If You Have Cervical Cancer | Cervical Cancer Short Guide
When cancer cells do this, it’s called metastasis. To doctors, the cancer cells in the new place look just like the ones from the cervix. Cancer is always named for the place where it starts. So when cervical cancer spreads to the lung (or any other place), it’s still called cervical cancer.
Ultrastaging and Low-Volume Metastatic Disease in Early-Stage Cervical …
The sentinel lymph node technique in early-stage cervical cancer—when to perform it, its process, as well as the surgical specimen—continues to be a challenge for gynecologists, oncologists, and pathologists in order to plan the therapeutic strategy. The objective of this paper is to describe the state of the art and provide a critical point of view about these topics.
Recurrent or primary metastatic cervical cancer: current and …
2022年9月12日 · In this review, we discuss historical, current, and emerging treatment options for patients with primary metastatic or recurrent CC. Historically, disseminated recurrent CC was treated with cisplatin monotherapy that was considered as the standard of care (SOC) since the results of the phase II Gynecologic Oncology Group (GOG)-26 trial.
Cervical cancer stages - stage 1, stage 2, stage 3, stage 4
Early-stage cervical cancer – this usually includes stages 1A to 1B1. Locally advanced cervical cancer – this usually includes stages 1B2 to 4A. Advanced-stage or metastatic cervical cancer – this usually means stage 4B. If the cancer comes back after initial treatment, this is known as recurrent cancer. Who can I talk to for support?
Cervical lymph node metastasis (radiologic criteria)
2022年5月19日 · Cervical lymph node metastases refer to regional nodal involvement by cancer in the head and neck, most commonly due to squamous cell carcinoma originating from the aerodigestive tract or skin. Radiologic detection of cervical lymph node metastases is important for clinical staging and planning of surgery and radiotherapy.
Unusual Metastasis from Carcinoma Cervix - PMC - PubMed …
Three patients developed metastasis at unusual sites involving breast, paraspinal muscles, and duodenum which are very rarely involved. These patients were treated with chemotherapy using carboplatin and Paclitaxel combination but succumbed within 8–10 …
The 4 Stages of Cervical Cancer - Verywell Health
2024年6月23日 · Stage 1 is localized cancer that has not spread outside of the cervix into lymph nodes or other organs. In this stage, the cancer cells have grown and spread from the surface of the cervix into deeper tissues within the cervix. People with stage 1 …
Thyroid metastases from cervical carcinoma: unusual implications …
2024年12月20日 · The main routes of cervical cancer spread include local invasion (the most common), lymphatic dissemination, and hematogenous dissemination (typically spreading to lungs, liver, or bones). Despite its extensive blood supply, the thyroid gland is an uncommon metastatic site for primary neoplasms elsewhere. The mechanism of metastasis from ...
Neratinib Joins NCCN Guidelines for HER2-Mutated Cervical Cancer
4 天之前 · Friedman CF, D'Souza A, Bello Roufai D, et al. Targeting HER2-mutant metastatic cervical cancer with neratinib: final results from the phase 2 SUMMIT basket trial. Gynecol Oncol . 2024;181:162-169 ...
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer ...
2021年11月11日 · Background: Pembrolizumab has efficacy in programmed death ligand 1 (PD-L1)-positive metastatic or unresectable cervical cancer that has progressed during chemotherapy. We assessed the relative benefit of adding pembrolizumab to chemotherapy with or without bevacizumab. Methods: In a double-blind, phase 3 trial, we randomly assigned patients with …
Immunotherapy for Metastatic Cancer on the Rise, Even Near End …
2024年1月4日 · The study included 20,415 stage IV metastatic melanoma patients,197,331 stage IV non-small cell lung cancer patients (NSCLC), and 24,625 stage IV renal cell carcinoma (RCC) patients treated with immune checkpoint inhibitors from 2012 to 2019 for metastaic melanoma patients and from 2016 to 2019 for NSCLC and RCC patients.
Gastric and colonic metastasis from cancer cervix: An unusual ...
Gastric lesions are identified in less than 2% of patients with cancer of cervix and are usually asymptomatic. [1] . Melanoma, lung, breast and esophagus are the common primary metastatic sites. [2] . Symptoms of metastatic tumors include pain, vomiting and bleeding but are nonspecific.
Survival with Cemiplimab in Recurrent Cervical Cancer
2022年2月9日 · Toripalimab combined with bevacizumab plus chemotherapy as first-line treatment for refractory recurrent or metastatic cervical cancer: a single-arm, open-label, phase II study (JS001-ISS-CO214 ...
Pembrolizumab plus chemotherapy with or without bevacizumab …
2023年12月13日 · Evidence-based recommendations on pembrolizumab (Keytruda) plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer in adults.. Commercial arrangement. There is a commercial access agreement for pembrolizumab. NHS organisations can get details on the Commercial Access and Pricing …
Risk Assessment of Bone Metastasis for Cervical Cancer Patients …
Background: Population-based data on the risk assessment of newly diagnosed cervical cancer patients' bone metastasis (CCBM) are lacking. This study aimed to develop various predictive models to assess the risk of bone metastasis via machine learning algorithms.
Puma Biotechnology’s NERLYNX® Included in NCCN Clinical …
4 天之前 · About HER2-Mutated Cervical Cancer. Despite recent advancements in the therapeutic landscape for recurrent and metastatic cervical cancer, there is a need to identify robust biomarkers to direct ...
Associations between ADC histogram analysis values and tumor …
2024年12月20日 · The complex interactions of the tumor micromilieu may be reflected by diffusion-weighted imaging (DWI) derived from the magnetic resonance imaging (MRI). The present study investigated the association between apparent diffusion coefficient (ADC) values and histopathologic features in uterine cervical cancer. In this retrospective study, prebiopsy …
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