Cereblon - Wikipedia
Cereblon is a protein that in humans is encoded by the CRBN gene. [5] The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans. [5]
The E3 ubiquitin ligase component, Cereblon, is an ... - Nature
2021年9月6日 · Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4 CRBN E3 ubiquitin ligase, induces cancer cell death by targeting key neo-substrates for degradation. Despite this clinical...
Molecular glue CELMoD compounds are regulators of cereblon
2022年11月3日 · Cereblon (CRBN) is a ubiquitin ligase (E3) substrate receptor protein co-opted by CRBN E3 ligase modulatory drug (CELMoD) agents that target therapeutically relevant proteins for degradation.
Cereblon: promise and challenges for combating human diseases
Cereblon (CRBN) is a substrate recognition protein in the E3-ligase ubiquitin complex. The binding target of CRBN varies according to tissues and cells, and the protein regulates various biological functions by regulating tissue-specific targets.
Cereblon: A Protein Crucial to the Multiple Functions of ...
2017年8月15日 · It is well known that cereblon is a key protein in autosomal recessive nonsyndromic mental retardation. Studies have reported that it has an intermediary role in helping immunomodulatory drugs perform their immunomodulatory and tumoricidal effects.
The E3 ligase adapter cereblon targets the C-terminal cyclic imide ...
2022年10月19日 · Cereblon (CRBN) is a conserved protein that functions as a substrate recognition adapter in the CRL4 CRBN E3 ubiquitin ligase complex.
Cereblon in health and disease | Pflügers Archiv - Springer
2016年6月24日 · Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that has been linked to autosomal recessive non-syndromic mental retardation. Several key findings suggest diverse roles of CRBN, including its regulation of the large-conductance calcium- and voltage-activated potassium (BK Ca ) channels, regulation of thalidomide ...
Cereblon - an overview | ScienceDirect Topics
Cereblon (CRBN) modulates diverse biological functions in cancer and neural cells. CRBN exhibits both the ubiquitination-dependent and -independent functions. IMiDs regulate CRBN functions through enhancing its ubiquitination function or disrupting its interacting proteins.
Cereblon: promise and challenges for combating human diseases …
2021年9月22日 · Cereblon (CRBN) is a substrate recognition protein in the E3-ligase ubiquitin complex. The binding target of CRBN varies according to tissues and cells, and the protein regulates various biological functions by regulating tissue-specific targets.
Multiple cereblon genetic changes are associated with acquired ...
2021年1月14日 · Cereblon (CRBN) is the essential binding protein of the widely used immunomodulatory drugs (IMiDs) and novel CRBN E3 ligase modulator drugs (CELMoDs) in myeloma, as well as certain proteolysis targeting chimeras (PROTACs), in development for a range of diseases.