Plasma membrane integrity in health and disease: significance …
2021年1月19日 · Fundamentally, irrespective of the source of membrane disruption, aberrant calcium influx is the common stimulus that activates the membrane repair response. Inadequate repair responses can...
Intracellular Delivery by Membrane Disruption: Mechanisms, …
In this section we will discuss cell and membrane properties, mechanisms of membrane disruption, and cell response to membrane disruption. These background concepts lay a foundation to explore the common issues that arise in …
Plasma membrane integrity: implications for health and disease
2021年4月13日 · Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity.
Intracellular Delivery by Membrane Disruption: Mechanisms, …
2018年7月27日 · Here, we review techniques for membrane disruption-based intracellular delivery from 1911 until the present. These methods achieve rapid, direct, and universal delivery of almost any cargo molecule or material that can be dispersed in solution.
In vitro and ex vivo strategies for intracellular delivery | Nature
2016年10月12日 · Here we review in vitro and ex vivo intracellular delivery approaches with a focus on mechanisms, challenges and opportunities. In particular, we emphasize membrane-disruption-based delivery...
Visualizing the membrane disruption action of antimicrobial
2023年9月6日 · Our high-resolution cryo-ET images reveal how pepD2M disrupts the E. coli membrane using a carpet/detergent-like mechanism. Our studies reveal the direct membrane-disrupting consequence of AMPs...
Intracellular Delivery by Membrane Disruption: Mechanisms ... - PubMed
2018年8月22日 · Here, we review techniques for membrane disruption-based intracellular delivery from 1911 until the present. These methods achieve rapid, direct, and universal delivery of almost any cargo molecule or material that can be dispersed in solution.
Membrane Interactions and Toxicity by Misfolded Protein …
2021年3月11日 · These include the membrane disruption model, resulting in calcium imbalance, mitochondrial dysfunction and intracellular reactive oxygen species, and the direct interaction with membrane proteins, leading to the alteration of their native function.
Plasma membrane disruption: repair, prevention, adaptation
Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages.
Switching from membrane disrupting to membrane crossing, an …
2023年1月25日 · Here, we report an effective strategy to optimize antimicrobial peptides by switching membrane disrupting to membrane penetrating and intracellular targeting by breaking the helical structure using racemic residues.
- 某些结果已被删除