Cell cycle regulation: p53-p21-RB signaling - Nature
2022年3月31日 · Facts. The tumor suppressor p53 can induce cell cycle arrest. Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase …
Multiple functions of p21 in cell cycle, apoptosis and ... - PubMed
Cyclin-dependent kinase (CDK) inhibitor p21 (also known as p21 (WAF1/Cip1)) is one of these factors that promote cell cycle arrest in response to a variety of stimuli. The inhibitory effect of …
Multiple functions of p21 in cell cycle, apoptosis and …
2016年6月1日 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. …
Biology of the cell cycle inhibitor p21(CDKN1A): molecular …
The cell cycle inhibitor p21 (CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The …
p21 in cancer: intricate networks and multiple activities - PMC
The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an …
Cell cycle regulation by the intrinsically disordered proteins, p21 …
We have reviewed how the intrinsic disorder of p21 and p27 mediates cell cycle regulation and have highlighted functional advantages associated with disorder. p21 promiscuously binds to …
Cell cycle regulation: p53-p21-RB signaling - PubMed
Following activation of p53, for example by viral infection or induction of DNA damage, p21 expression is upregulated. High levels of p21 then result in RB-E2F complex formation and …
p21 in Cancer Research - PMC - PubMed Central (PMC)
2020年8月14日 · p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models …
p21 in cancer: intricate networks and multiple activities
2009年5月14日 · The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function...
Biology of the cell cycle inhibitor p21 - Springer
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The …