Caspase-9 - Wikipedia
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, [5] critical to the apoptotic pathway found in many tissues. [6] Caspase-9 homologs have been identified in all mammals for which they are known to exist, such as …
caspase - 百度百科
发生同源活化的Caspase又被称为启动Caspase（initiator Caspase），包括Caspase-8、Caspase-9、Caspase-10。 诱导 凋亡 后，起动Caspase通过连接物adaptor被召集到特定的起始活化 复合体 ，形成同源二聚体构像改变，导致同源分子之间的 酶切 而自身活化。
胱天蛋白酶9 - 维基百科，自由的百科全书
胱天蛋白酶9（英语：Caspase 9）是人类中由CASP9基因编码的一种酶。它是一种启动型胱天蛋白酶， [6] 对于许多组织中发现的细胞凋亡途径至关重要。 [7] 已经在已知存在的所有哺乳动物中发现了胱天蛋白酶9同源物，如小鼠（Mus musculus）和黑猩猩（Pan troglodytes）。 [8]
细胞凋亡研究|细胞凋亡的引路者：Caspase家族 - 知乎
2023年12月8日 · 促凋亡因子细胞色素C与凋亡蛋白酶激活因子-1（Apaf-1）结合形成凋亡小体接近caspase 9单体导致其二聚化并产生蛋白水解信号，进而激活caspase 3和7引发细胞凋亡。
Caspase-9: structure, mechanisms and clinical application
2017年4月4日 · As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thoug …
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular ...
2021年7月8日 · Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue...
Caspases in cell death, inflammation and disease - PMC
Akin to apoptotic initiator caspase-9, the prototypical inflammatory caspase-1 harbours a CARD in its amino-terminal propeptide through which it gets recruited into inflammasomes, cytosolic multi-protein complexes that support caspase-1 dimerization and …
Cell-to-cell variability in inducible Caspase9-mediated cell death
2022年1月10日 · Zhang P, Raju J, Ullah MA, Au R, Varelias A, Gartlan KH, et al. Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential...
Caspases and their substrates | Cell Death & Differentiation - Nature
2017年5月12日 · Apoptosis can also be induced by internal factors (intrinsic), such as DNA damage, leading to activation of caspase-9 through mitochondrial cytochrome c release, Apaf1 oligomerization and ...
Caspase function in programmed cell death - Nature
2006年11月3日 · Caspase-9 is a key component of the mitochondrial death pathway (the intrinsic pathway) that is regulated primarily by the Bcl-2 family and the BH-3 (Bcl-2 homology domain-3)-only proteins. 8,...