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Examination of the cerebrospinal fluid (CSF) provides important diagnostic information in many infectious and noninfectious medical conditions of the nervous system. Understanding the physiology of CSF production and flow and the composition of CSF aids in both evaluation and diagnosis and can guide therapy.
Normal pressure hydrocephalus - UpToDate
2024年5月31日 · NPH is a form of communicating hydrocephalus and is distinguished from obstructive or noncommunicating hydrocephalus, in which there is a structural blockage of the cerebrospinal fluid (CSF) circulation within the ventricular system …
Post dural puncture headache - UpToDate
2024年2月14日 · CSF hypotension results in compensatory meningeal venodilation and blood volume expansion, with headache caused by acute venous distention. This mechanism is consistent with magnetic resonance imaging (MRI) in several reported cases of PDPH [ 1,2 ].
Idiopathic intracranial hypertension (pseudotumor cerebri
2024年4月1日 · It is a disorder defined by clinical criteria that include symptoms and signs isolated to those produced by increased intracranial pressure (ICP; eg, headache, papilledema, double vision, transient visual obscurations, and vision loss), elevated ICP with normal cerebrospinal fluid (CSF) composition, and no other cause of intracranial ...
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2024年1月30日 · Intracranial hypotension most commonly occurs from a persistent CSF leak after lumbar puncture but may also be spontaneous. This topic will review the treatment and prognosis of spontaneous intracranial hypotension.
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Therefore, the time course of the ICP appears to be determined by the frequency of the fundamental units of abnormal synchronized activity (the epileptogenic spike) and the CSF pressure-volume dynamics existing at the time of the seizure.
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A live cell-based assay assessed CSF MOG-IgG positivity (IgG-binding-index [IBI],≥2.5) using multiple anti-human secondary antibodies and end-titers were calculated if sufficient sample volume. Correlation of CSF MOG-IgG IBI and titer was assessed.
Cranial cerebrospinal fluid leaks - UpToDate
2025年1月2日 · CSF flows externally down a pressure gradient to cause clear rhinorrhea or otorrhea, the leakage of CSF into the nose or ear. The condition was first described in 1899 by St Clair Thompson . Extradural CSF leakage may also lead to neurologic symptoms from changes in intracranial volume and pressure.
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Calculator: Adjusted cerebrospinal fluid white blood cell count in the presence of red blood cells
Cerebrospinal fluid: Physiology and utility of an ... - UpToDate
2023年8月16日 · In normal adults, the CSF volume is 90 to 200 mL ; approximately 20 percent of the CSF is contained in the ventricles; the rest is contained in the subarachnoid space in the cranium and spinal cord. The normal rate of CSF production is approximately 20 mL per hour.