Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle …
2017年10月18日 · Cyclin-dependent kinase 2 (Cdk2) is a key cell cycle regulator, with roles in inactivating phosphorylation of the RB1 (pRb) tumour suppressor family and in controlling both G1/S and G2/M...
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis ...
2024年5月14日 · Cyclin-dependent kinases (CDKs), particularly CDK4 and CDK2, are crucial for cell cycle progression from the Gap 1 (G1) to the Synthesis (S) phase by phosphorylating targets such as the Retinoblastoma Protein (Rb).
Inhibition of the CDK2 and Cyclin A complex leads to autophagic ...
2022年5月20日 · Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 are ATP...
Cyclin-Dependent Kinases (CDK) and Their Role in Diseases …
2021年3月13日 · In dividing cells, cyclin-dependent kinase 2 (CDK2) is a major cell cycle component that controls the G1/S and S/G2 transitions. CDK2/CycE must phosphorylate Rb to induce S phase entry ( mouse embryonic fibroblasts–MEFs ) [ 22 ].
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle ...
2023年6月1日 · While treatment of cells with PF3600 leads to an immediate reduction of CDK2 kinase activity, these cells rapidly adapt via a CDK2/4/6-Rb-E2F-dependent mechanism that circumvents CDK2 inhibition and enables cell-cycle completion.
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle ...
2023年6月8日 · CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target. Here, we use several CDK2 inhibitors in clinical development to interrogate CDK2 substrate phosphorylation, cell-cycle progression, and drug adaptation in …
Targeting CDK2 in cancer: challenges and opportunities for therapy
2020年2月1日 · CDK2 has key roles in cell cycle, DNA replication and DNA damage. •. Multiple biomarkers can indicate increased CDK2 activity. •. Some cancers have particular susceptibility to CDK2 inhibition. •. The development of selective CDK2 inhibitors is challenging.
Slower CDK4 and faster CDK2 activation in the cell cycle
2024年8月8日 · Cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases essential for cell cycle regulation. 1,2,3 Among them, CDK2 and CDK4 are crucial for the initiation of DNA replication and progression from the G1 to the S phase.
A review on the role of cyclin dependent kinases in cancers
2022年10月20日 · The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers.
Cell cycle, CDKs and cancer: a changing paradigm - Nature
Recent genetic studies indicate that CDK2, CDK4 and CDK6 are not essential for the mammalian cell cycle. Instead, they are only required for the proliferation of specific cell types. By...