2020年9月15日 · Persistent exposure of CD8 + T cells to tumour neoantigens can induce the sustained expression of immune-checkpoint molecules, which characterises—and might drive—the dysfunctional state ...

2023年8月3日 · The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8+ T cells recognizing cognate antigens presented in the context of target cell...

2023年8月3日 · Nature Cancer - CD8+ T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8+ T cells eliminate cancer cells...

Here, we report that CD8 + T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. This capacity proves to be dependent instead on interactions between T cell natural killer group 2D (NKG2D) and tumor NKG2D ligands (NKG2DLs), the latter of which are highly expressed on MHC-loss variants.

2025年1月17日 · In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8 + T cell fates in cancer, drawing on insights from acute and chronic viral infection models. We highlight the role of DCs in lymph nodes and tumors in maintaining stem-like CD8 + T cells, which are

Persistent exposure of CD8 + T cells to tumour neoantigens can induce the sustained expression of immune-checkpoint molecules, which characterises—and might drive—the dysfunctional state called T-cell exhaustion, in which simple removal of the antigen does not induce recovery. 25 Exposure of CD8 + cells to antigens for only a few weeks led ...

Upon activation, effector CTLs infiltrate to the core or invading site of the tumor (so-called infiltrated-inflamed [I-I] TME) and take essential roles for killing cancer cells. Exogenous reactivation and/or priming of CD8 + T cells can be possible …

CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, and colleagues review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates T cell metabolism and the impact of the tumor microenvironment.

We demonstrated that splenocytes and tumor-infiltrating T cells derived from mice treated with combination therapy were able to kill approximately 50% of target cells after 48 h of co-culture. This effect was tumor cell-specific and dependent on CD8 + …

2020年12月1日 · In this study, we combine an intracellular flow cytometry- and luminescence-based viability assay to assess CD8 + T cell-dependent cytotoxicity of tumor cells and tumor-specific activation of effector cytotoxic CD8 + T cells. Assay functionality was evidenced using primary immune cells from two different mouse strains, bearing Lewis lung ...